Cefaclor s-a dovedit eficace atat in infectiile acute, cat si in infectiile cronice ale tractului urinar. Infectiile pielii si ale tesuturilor moi determinate de Staphylococcus aureus si Str. Pentru determinarea susceptibilitatii microorganismelor incriminate la cefaclor ar trebui efectuate culturi si studii de susceptibilitate. Ceclor cefaclor monohidrat USP, Lilly , este un antibiotic semisintetic din clasa cefalosporinelor, pentru administrare orala.

Din punct de vedere chimic este 3-cloroD- 2-fenilglicinamido cefemcarboxilic acid monohidrat. Doza uzuala este de mg la 8 ore. Nu a fost stabilita eficacitatea si siguranta administrarii in cazul nou-nascutilor sub o luna. De obicei, nu sunt necesare modificari ale dozajului in cazul pacientilor cu insuficienta renala moderata sau severa vezi "Precautii speciale in utilizare". Precautii speciale in utilizare: Inainte de introducerea terapiei cu cefaclor, trebuie luate in considerare cu multa grija preexistenta unor reactii de hipersensibilitate la cefalosporine, peniciline sau alte medicamente.

Daca acest produs va fi administrat pacientilor sensibili la penicilina, trebuie avut grija pentru ca au fost inregistrate si cazuri de soc anafilactic dupa administrarea antibioticelor beta-lactamice in cazul pacientilor hipersensibili.

Medicamentul trebuie administrat cu multa grija si in cazul pacientilor cu episoade alergice cunoscute. Colita pseudomembranoasa a fost raportata in cazul administrarii majoritatii antibioticelor cu spectru larg. Other effects considered related to therapy included eosinophilia 1 in 50 patients , genital pruritus, moniliasis or vaginitis about 1 in 50 patients , and, rarely, thrombocytopenia or reversible interstitial nephritis. Causal Relationship Uncertain - CNS - Rarely, reversible hyperactivity, agitation, nervousness, insomnia, confusion, hypertonia, dizziness, hallucinations, and somnolence have been reported.

Transitory abnormalities in clinical laboratory test results have been reported. Although they were of uncertain etiology, they are listed below to serve as alerting information for the physician. Renal - Slight elevations in BUN or serum creatinine less than 1 in or abnormal urinalysis less than 1 in Cephalosporin-class Adverse Reactions In addition to the adverse reactions listed above that have been observed in patients treated with Cefaclor, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics: Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced.

If seizures associated with drug therapy occur, the drug should be discontinued. Overdosage Signs and Symptoms - The toxic symptoms following an overdose of Cefaclor may include nausea, vomiting, epigastric distress, and diarrhea. The severity of the epigastric distress and the diarrhea are dose-related. If other symptoms are present, it is probable that they are secondary to an underlying disease state, an allergic reaction, or the effects of other intoxication.

Treatment - To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient. Unless 5 times the normal dose of Cefaclor has been ingested, gastrointestinal decontamination will not be necessary.

Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient's vital signs, blood gases, serum electrolytes, etc. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying.

Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. Contents of the pack and other information 1. What Cefaclor is and what it is used for Cefaclor belongs to a group of antibiotic medicines called cephalosporins and works by killing bacteria that cause infections. Cefaclor is used to treat the following: What you need to know before you take Cefaclor Do not take Cefaclor if: This includes herbal medicines.

Medicines which may interact with or be affected by Cefaclor: Trebuie efectuata antibiograma pentru a determina etiologia infectiei si sensibilitatea germenilor la cefaclor.

Antibioticele, inclusiv cefaclorul, trebuie administrate cu prudenta la pacientii cu orice forma de alergie, in special alergie la medicamente. Trebuie avut in vedere ca tratamentul de lunga durata poate determina dezvoltarea de microorganisme rezistente. Pacientul trebuie tinut sub supraveghere atenta.

Daca in timpul tratamentului apare o suprainfectie, trebuie adoptate masurile adecvate. Interactiuni Rareori, s-a raportat cresterea efectului anticoagulant in cazul administrarii concomitente de cefaclor si anticoagulante orale. Teste de laborator In timpul tratamentului cu cefaclor pot sa apara rezultate fals pozitive ale testului Coombs direct. Pot sa apara reactii fals pozitive la determinarea glucozei in urina prin utilizarea solutiilor Benedict, Fehling sau a comprimatelor de sulfat de cupru.

Ca si in cazul altor antibiotice beta-lactamice, excretia renala a cefaclorului este inhibata de administrarea probenecidului. Evenimente anafilactoide pot deveni manifeste ca edem angioneurotic, astenie, edeme ale fetei si membrelor , dispnee, parestezii, sincopa sau vasodilatatie. Tulburari hematologice si limfatice: Tulburari renale si ale cailor urinare: Tulburari ale aparatului genital si sanului: Tulburari ale sistemului nervos: Severitatea durerilor epigastrice si a diareei sunt dependente de doza.

Deoarece nu exista un antidot specific, in caz de supradozaj, se recomanda tratament simptomatic si de sustinere a functiilor vitale si administrarea de carbune activat. Cefaclor este un antibiotic beta-lactamic care apartine grupului cefalosporinelor. Similar altor antibiotice beta-lactamice, cefaclor inhiba biosinteza peretelui celular al bacteriilor aflate in faza de multiplicare.

Similar altor cefalosporine din prima si a doua generatie, cefaclor este numai moderat rezistent la degradarea de catre beta lactamaze, cu toate acestea, este rezistent la penicilinaza. Spectrul general de actiune Urmatoarele microorganisme Gram-pozitiv si Gram-negativ sunt considerate sensibile:

Cefaclor Terapia, 250 mg/5 ml / 125 mg/5 ml, granule pentru suspensie orală

La o ora de la administrare au sirop detectate cantitati foarte mici de cefaclor in lapte, ceclor 250mg sirop. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Tratament Pe langa tratamentul simptomatic sirop de sustinere, sirop intestinala poate fi scazuta prin inducerea varsaturilor, lavaj gastric si administrarea de carbune activat. Dupa reconstituire suspensia se va pastra la frigider, ceclor 250mg sirop. Cefaclor should be administered with caution ceclor the presence of markedly impaired renal function. 250mg s-au efectuat studii privind administrarea cefaclor la femeile care alapteaza; totusi, dupa administrarea unei doze unice de ceclor cefaclorul 250mg excreta in laptele matern. Diureza fortata, dializa peritoneala, hemodializa sau ceclor nu s-au dovedit 250mg in accelerarea eliminarii Ceclor. Un numar mic de sirop au prezentat diaree si, rar, greata si varsaturi. Cases of serum-sickness-like reactions have been ceclor with the use of Cefaclor. What is 250mg this leaflet:

Cefaclor, 125 mg/5 ml / 250 mg/5 ml, granule pentru suspensie orală

Nu s-a 250mg stabili un tipar al asocierii acestei simptomatologii cu tratamente anterioare sau concomitente. Tratamentul trebuie continuat cel putin 10 zile cand se trateaza sinuzite si infectii determinate de streptococi beta-hemolitici. Medicines which may interact with or be affected by Cefaclor: Contraindications Cefaclor is contraindicated in patients with known allergy to the cephalosporin group of ceclor. In cazul infectiilor severe 250mg exemplu pneumonia sau al celor produse de microorganisme mai putin sensibile, ceclor 250mg sirop, dozele pot fi dublate. Aceste reactii apar mai frecvent la copii decat la adulti. Anafilaxia poate sa ceclor mai frecvent la sirop cu alergie la peniciline. Adulti Doza uzuala recomandata la adulti este de mg cefaclor la intervale de 8 ore. In general, ceclor 250mg sirop, divalproex for bipolar disorder simptome alergice apar in timpul sau dupa al doilea ciclu de tratament cu cefaclor, mai frecvent la copii decat la adulti si scad in intensitate in cateva zile dupa oprirea tratamentului. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Pentru reconstituirea suspensiei de cefaclor, peste granulele din flacon se adauga 45 sirop apa fiarta si racita in prealabilin doua etape. Cefaclor este excretat in laptele uman. Supradozajul cu cefalosporine poate produce convulsii. Daca acest produs va fi administrat pacientilor sensibili la penicilina, trebuie avut grija pentru ca au fost inregistrate si cazuri de soc anafilactic dupa administrarea antibioticelor beta-lactamice in cazul pacientilor hipersensibili.

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