It actually usually gets so bad I have to go talk to my doctor about my weight loss. I can stomach food but it comes out in liquid form within 15 mins and clears my system. This drug is a major weight loss drug from me. I know everytime I start it it's a given I will be losing 10 pounds minimum. The first attempt lasted a week; as it can exaggerate the effects of other meds, I became so drowsy I couldn't drive.
For the second attempt, it wasn't combined with any other medication and lasted 3 weeks. I felt continually agitated and anxious, began to quickly gain weight, had terrible gas and was going to the bathroom times a day.
Additionally, my hair began to fall out so quickly, even my husband noticed and he's NOT very observant! The most disturbing symptom was the frequent presence of pronounced, irregular heart beats and at least one near-syncopal episode. All this in just 21 days- thanks but no thanks! After 10 years on Lamictal as monotherapy, with continued mania and depression. I was hospitalized and switched to Depakote. Good thing I have thick hair or I could have been bald at the end of this drug.
I don't recommend this to anyone. It was like taking poison. The last one I was on before Depakote was lamotrigine which really is better for bipolar II, from what I understand. I tend to run very manic and don't have a thyroid anymore - cancer , so my doc and I decided this would probably be my best option.
None of the new drugs worked on me. Depakote has been amazing. I can think a lot more clearly and I'm still me - just a lot more toned down. I've had no negative side effects except a slight tremor, but I'm also on xanax for severe anxiety, so its only noticeable when it's time for that. No weight gain, either. In fact, my appetite decreased. A long period of feeling worried or empty Loss of interest in activities once enjoyed, including sex Feeling tired or slowed down Having problems concentrating, remembering and making decisions Being restless or irritable Chang in eating, sleeping or other habits Thoughts of death or suicide, or attempting suicide.
Symptoms of hypomania or hypomanic episode: Hypomania is a less severe form of mania. Another antipsychotic, lurasidone Latuda , is approved for use in bipolar I depression as is the combination of olanzapine plus fluoxetine called Symbyax.
The antipsychotic quetiapine Seroquel is approved to treat bipolar I or II depression. Preliminary studies also suggest that the atypical antipsychotic cariprazine Vraylar also may have value for treating bipolar depression Continued Some of these drugs can potentially become toxic if doses get too high. Therefore, they need to be monitored periodically with blood tests and clinical assessments by the prescriber.
Because it is often difficult to predict which patient will react to what drug or what the dosage should ultimately be, the psychiatrist will often need to experiment with several different medications when beginning treatment. While antidepressants remain widely prescribed for bipolar depression, most antidepressants have not been adequately studied in patients with bipolar depression.
In general, your doctor may try to keep the use of antidepressants limited and brief. Ask your healthcare provider about the best way to feed your baby. Taking Depakote with certain other medicines, even for a short period of time, can cause side effects or affect how well they work.
Do not start or stop other medicines without talking to your healthcare provider. Depakote can cause other serious side effects, including: High ammonia levels in your blood: Low body temperature hypothermia: Drowsiness or sleepiness in the elderly.
Therapeutic drug monitoring, particularly serum valproic acid levels, were not mentioned in the design of the study and were not reported. Adherence, one of the secondary outcome measures, was patient rated and evaluated by a telephone interview conducted by the raters. Statistical analysis was not performed on the data collected. Utilizing the statistical method of repeated measures analysis, statistically significant improvement was noted from the time of conversion to study endpoint with both the HAM-D 21 and YMRS.
No significant changes were identified in therapeutic drug monitoring lab values and overall patients reported improved tolerability of the ER formulation. The use of ER in the management of psychiatric symptoms has not been limited to bipolar disorder alone. One 4-week, open-label DR to ER conversion study included thirty patients diagnosed with schizophrenia Citrome, Tremeau et al Patients were converted at a 1: Dosing required the use of mg increments due to the lack of availability of the mg tablet at the time of the study.
Twenty-seven of 30 patients completed the 4-week study. The baseline mean BPRS total score was Significant improvement was noted for the 1: Mean UKU scores also showed significant improvement, dropping from a mean of 8. The conversion of DR to ER was not associated with any reports of psychiatric decompensation. The improvement of UKU scores are consistent with other reports of improved tolerability associated with the ER formulation.
Conclusion Current literature evaluating the use of ER in psychiatric patients with bipolar disorder suggests the ER formulation has advantages over the DR formulation. In contrast to DR, the ER formulation provides a dosage form of divalproex that is pharmacokinetically supported for once-daily dosing. While the studies included in this review were not specifically designed to examine differences in medication compliance rates, a correlation between once daily dosing and medication adherence has been established.
Of additional benefit, ER had improved tolerability over DR, likely the result of lower peak plasma concentrations without apparent risk of lost efficacy. The studies included in this review article are greatly limited when utilizing a strict evidence based medicine review procedure.
I'm now on an antidepressant and waiting These defects occur in 1 to 2 out of every divalproex born to mothers who use this medicine during pregnancy. Hope this helps someone. No additional medication changes were allowed during the week observation period. In fact, my disorder decreased. This extreme drowsiness may cause you to eat or drink less than you normally would. Depakote can cause other serious side effects, including: Do not stop taking Depakote without first talking to your healthcare provider. For from epidemiologic studies concluded that children born to women who take valproate sodium or related products valproic acid, divalproex sodium during pregnancy have an increased risk for lower cognitive test scores, compared with children exposed to other antiseizure medications during pregnancy. I tried lamictal and abilify and I hated them. None of the new drugs worked on me. The mean baseline GAF score was Divalproex sodium is bipolar to cause neural tube defects; evidence suggests that folic acid supplementation prior to conception and during the first trimester decreases risk for congenital neural tube defects Divalproex sodium is excreted in breast milk ; use caution while breastfeeding. Practice guideline generic zyrtec d prices the treatment of patients with schizophrenia, divalproex for bipolar disorder, second edition. Depakote is known to work wonders for mania, divalproex for bipolar disorder, and I can attest to this effect being noticeable right away.
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