Atorvastatin 20mg ndc

A history of renal 20mg may be a risk factor for atorvastatin development of rhabdomyolysis. Such patients merit closer monitoring for ndc muscle effects. The concomitant use of higher doses of atorvastatin with certain drugs such as cyclosporine and strong CYP3A4 inhibitors e. There ndc been rare reports of immune-mediated necrotizing myopathy IMNMan autoimmune myopathy, associated with statin use.

IMNM is characterized by: Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if muscle signs and symptoms ondansetron 4mg after discontinuing LIPITOR.

The risk of myopathy during treatment with drugs in this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, erythromycinclarithromycin, the hepatitis C protease inhibitor telaprevir, combinations of HIV protease inhibitors, including saquinavir plus ritonavir, lopinavir plus ritonavir, atorvastatin 20mg ndc, tipranavir plus ritonavir, darunavirplus ritonavir, fosamprenavir, and fosamprenavir plus ritonavir, niacinor azole antifungals.

Physicians considering combined therapy 20mg LIPITOR and fibric acid derivatives, erythromycin, clarithromycin, atorvastatin 20mg ndc, a combination ofsaquinavir plusritonavir, lopinavir plus ritonavir, darunavir plusritonavir, fosamprenavir, or fosamprenavir plus ritonavir,azole antifungals, or lipid -modifying doses of niacin should carefully weigh the potential benefits and risks and should carefully monitor patients for any ndc or symptoms of muscle pain, tenderness, or weakness, particularly during the initial months of therapy and during any periods of upward dosage titration of either drug.

Periodic creatine phosphokinase CPK determinations may be considered in such situations, but there is no assurance that such monitoring will prevent the occurrence of severe myopathy. LIPITOR 20mg should be temporarily withheld or discontinued atorvastatin any patient with anacute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis e.

Liver Atorvastatin Statins, like some other lipid-lowering therapies, have been associated with biochemical abnormalities of liver function.

The incidence of these abnormalities was 0. One patient in clinical trials developed jaundice. Increases in liver function tests LFT in other patients were not 20mg with jaundice or other clinical signs or symptoms. Upon dose reduction, drug interruption, or ndc, transaminase levels returned to or near pretreatment levels without sequelae, atorvastatin 20mg ndc.

There have been rare post marketing reports of fatal and non-fatal hepatic failure in patients taking statins, atorvastatin 20mg ndc, including clotrimazole buy online. The effects of statins on male fertility atorvastatin not been studied in adequate numbers of patients.

Atorvastatin Treats Cholesterol Levels and Prevents Heart Disease - Overview

The effects, if atorvastatin, oftan timolol 5mg the pituitary -gonadal axis in premenopausal women are unknown.

Caution should be exercised if a statin is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroidhormones, atorvastatin 20mg ndc, such as ketoconazolespironolactone, and cimetidine.

CNS vascular lesions, characterized by perivascular hemorrhages, atorvastatin 20mg ndc, edema, and mononuclear cell infiltration of perivascular spaces, have been observed in dogs treated with other members of this class. A chemically similar drug in this class produced optic nerve degeneration Wallerian degeneration of retinogeniculate fibers in clinically normal dogs in a dose-dependent fashion at a dose that produced plasma drug levels about 30 times higher than the mean drug level in humans taking the highest recommended dose.

The incidence of fatal hemorrhagic stroke was similar across treatment groups 17 vs. The incidence of nonfatal hemorrhagic 20mg was significantly higher in the atorvastatin group 38, 1. Patients taking LIPITOR shouldbe advised that cholesterol is a chronic condition and they should adhere to their medication along with their National Cholesterol Education Program NCEP -recommended diet, a regular exercise program as appropriate, and periodic testing of a fasting lipid panel to determine goal attainment, atorvastatin 20mg ndc.

Muscle Pain All patients starting therapy with LIPITOR should be advised of atorvastatin risk of myopathy and told to report promptly any unexplained muscle 20mg, tenderness, or weakness particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing LIPITOR. They should discuss all medication, both prescription and over the counter, with their healthcare professional, atorvastatin 20mg ndc.

All patients treated with LIPITOR should be advised to report promptly any symptoms that may indicate liver injury, including fatigue, anorexiaright upper abdominal discomfort, dark 20mg, or jaundice. This dose represents a plasma AUC metoprolol (toprol-xl) 25mg 24 hr tablet of approximately 16times the mean atorvastatin plasma drug exposure after an 80 mg oraldose.

These findings occurred at plasma AUC values of approximately 6times the mean human plasma drug exposure after an 80 mg ndc dose. In vitro, atorvastatin was not mutagenic or clastogenic 20mg the following tests with and without metabolic activation: Atorvastatin was negativein the in vivo mouse micronucleus test. Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, LIPITOR may online pharmacy for accutane fetal harm when administered to a pregnant woman.

Limited ndc data on the use of atorvastatin are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage. The estimated back ground risk of major birth defects and miscarriage for the indicated population ndc unknown, atorvastatin 20mg ndc.

Data Human Data Limited published data on atorvastatin calcium from observational studies, meta-analyses and case report shave not shown an increased risk of major congenital malformations or miscarriage. Rare reports of congenital anomalies have been received following intrauterine exposure to other HMG-CoA reductase inhibitors. Animal Data Atorvastatin crosses the ndc placenta and reaches a level in fetal liver equivalent to that of maternal plasma.

atorvastatin

ATORVASTATIN CALCIUM: Package Insert and Label Information (Page 7 of 7)

There is no available information on the effects of atorvastatin drug on the breastfed infant or the effects of the drug on ndc production. It is not known whether at orvastatin is present in human milk, but it has been shown that another drug in this class passes into human milk and at orvastatin 20mg present in rat milk, atorvastatin 20mg ndc.

Because of the potential for serious adverse reactions in a breastfedinfant, advise women that breastfeeding is not recommended during treatment with LIPITOR. A placebo-controlled clinical trial of 6 months duration in boys and postmenarchal ndc years to 17 years of age.

Patients treated with 10 mg or20 mg daily LIPITOR had an adverse reaction profile generally similar to that of patients treated with placebo. In ndc limited controlled study, atorvastatin 20mg ndc, there was no significant effect on growth or sexual maturation in boys or on menstrual cycle length atorvastatin girls. The safety and efficacy of LIPITOR in lowering 20mg appeared generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design Advise postmenarchal girls of contraception recommendations, if appropriate for the patient [see Use in Specific Populations], atorvastatin 20mg ndc.

The long-term efficacy of LIPITOR therapy initiated inchild hood to reduce morbidity and mortality in adulthood has not been established. No overall differences in safety or atorvastatin were observed between these subjects and younger subjects, and other reported clinical experience has 20mg identified differences in responses between the elderly and younger patients, but greater sensitivity of someolder adults cannot be ruled out.