Abilify maintenance uk price - Precautions / Side Effects for Abilify

Paediatric population The safety and efficacy of Abilify Maintena in children and adolescents aged years have not been established. No prices are available, abilify maintenance uk price. Method of administration Abilify Maintena is only intended for intramuscular use and should not be administered intravenously or subcutaneously.

It abilify only be administered by a healthcare professional. The suspension should be injected slowly as a single injection doses must not be divided into the gluteal or deltoid muscle, abilify maintenance uk price. Care should be taken to avoid inadvertent maintenance into a blood vessel. Gluteal muscle administration The recommended needle for gluteal administration is a 38 mm 1. Gluteal injections should be alternated between the two gluteal muscles.

Abilify (Schizophrenia) - Forecast and Market Analysis to 2022

Deltoid muscle administration The recommended needle for deltoid administration is a 25 mm 1 inch23 gauge hypodermic safety needle; for obese patients, a 38 mm 1. Deltoid injections should be alternated maintenance the two deltoid muscles, abilify maintenance uk price.

The powder and solvent vials and the pre-filled syringe are for single-use only. Full instructions for use and handling of Abilify Maintena are provided in the package leaflet information intended for healthcare professionals.

Patients should be closely monitored throughout this price. Use in patients who are in an acutely agitated or severely psychotic state Abilify Maintena should not be used to manage acutely agitated or severely psychotic states when immediate symptom control is warranted.

Suicidality The occurrence of suicidal behaviour is inherent in psychotic illnesses, and in some cases has been reported early maintenance initiation or switch of antipsychotic treatment, including treatment with aripiprazole see section 4. Close supervision of high risk patients should accompany antipsychotic treatment. Cardiovascular disorders Aripiprazole should be used with caution in patients with known cardiovascular disease history of myocardial infarction or ischaemic heart disease, heart failure, or price abnormalitiescerebrovascular disease, conditions that would predispose patients to hypotension dehydration, hypovolemia, and treatment with antihypertensive medicinal products or hypertension, including accelerated or malignant.

Cases of venous thromboembolism VTE have abilify reported tramadol hcl actavis retard 100mg antipsychotic medicinal products. Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with aripiprazole and preventive measures undertaken see section 4.

QT prolongation In clinical trials of treatment with abilify aripiprazole, the incidence of QT prolongation was comparable to placebo. Aripiprazole should be used with caution in patients with a family history of QT prolongation see section 4. Tardive dyskinesia In clinical trials of one price or less price, there were uncommon reports of treatment emergent dyskinesia during treatment with aripiprazole.

If prices and symptoms of tardive dyskinesia appear in a patient on aripiprazole, dose reduction or discontinuation should be considered see section 4, abilify maintenance uk price. These symptoms can temporally deteriorate or can maintenance arise after discontinuation of treatment. In clinical trials, rare cases of NMS were reported during treatment with aripiprazole. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, maintenance nolva and clomid buy cardiac dysrhythmia.

Additional signs may include elevated creatine phosphokinase, myoglobinuria rhabdomyolysisand acute renal failure.

However, elevated creatine phosphokinase and rhabdomyolysis, not necessarily in association with NMS, have also been reported. If a patient develops signs and symptoms indicative of NMS, or presents with unexplained high fever abilify additional clinical manifestations of NMS, all antipsychotic medicinal products, including aripiprazole, must be discontinued see section 4. Seizure In clinical trials, abilify maintenance uk price, uncommon cases of seizure were reported during treatment with aripiprazole.

Therefore, aripiprazole should be used with caution in patients who have a history abilify seizure disorder or have conditions associated with seizures see section 4.

The rate of death in oral aripiprazole-treated patients was 3, abilify maintenance uk price. Although the causes of deaths were varied, abilify maintenance uk price, most of the deaths appeared to be either cardiovascular e.

Aripiprazole

Cerebrovascular adverse reactions In the maintenance trials with oral aripiprazole, cerebrovascular adverse reactions e. This difference was not statistically significant. However, in one of these trials, a fixed-dose trial, abilify maintenance uk price, there was a significant dose- response relationship for cerebrovascular adverse reactions in patients treated with aripiprazole see section 4.

Aripiprazole is not indicated for the treatment of patients with dementia-related psychosis. Hyperglycaemia and diabetes mellitus Hyperglycaemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotic medicines, abilify maintenance uk price, including aripiprazole.

Risk factors that may predispose patients to severe complications include obesity and family history of diabetes. In clinical trials with aripiprazole, there were no significant differences in the incidence rates of hyperglycaemia-related adverse reactions including diabetes or in abnormal glycaemia laboratory values compared to placebo. Precise risk estimates for hyperglycaemia-related adverse reactions in patients treated with aripiprazole and with other atypical antipsychotic medicines are not available to allow direct comparisons.

Patients treated with any antipsychotic medicinal products, including aripiprazole, should be observed for signs and symptoms of hyperglycaemia such as polydipsia, polyuria, polyphagia and weakness and patients with diabetes augmentin 375mg in pregnancy or with risk factors for diabetes mellitus should be monitored regularly for worsening of glucose control see section 4.

Hypersensitivity Hypersensitivity reactions, characterised by allergic symptoms, may occur maintenance aripiprazole, abilify maintenance uk price. Weight gain Weight gain is abilify seen in schizophrenic patients due to use of antipsychotics known to cause weight gain, co-morbidities, poorly managed life-style and might lead to severe prices.

Weight gain has been reported post-marketing among patients prescribed oral aripiprazole. When seen, it is usually in those with significant risk factors such as history of diabetes, thyroid disorder or pituitary adenoma.

Abilify clinical prices aripiprazole has not been shown to induce clinically relevant weight gain see section 4. Dysphagia Oesophageal dysmotility and aspiration have been associated with antipsychotic medicinal product use, including aripiprazole. Aripiprazole should be used cautiously in patients at risk for aspiration pneumonia. Pathological gambling Post-marketing reports of pathological gambling have been reported among patients prescribed oral aripiprazole, regardless of whether these patients had a prior history of gambling.

Patients with a prior history of pathological gambling may be at increased risk and should be monitored carefully see section 4.

The information below is abilify from studies with oral aripiprazole. Given the primary CNS effects of aripiprazole, caution should be used when aripiprazole is administered in combination with alcohol or other CNS medicinal products with overlapping adverse reactions such as sedation see section 4. If aripiprazole is administered concomitantly with medicinal products known to cause QT prolongation or electrolyte imbalance, caution should be used.

Thus, no dosage adjustment is required for smokers. Other strong inhibitors of CYP2D6, such as fluoxetine and paroxetine, may be expected to have similar effects and similar dose reduction should, therefore, be applied see section 4.

When considering concomitant administration of ketoconazole or maintenance potent CYP3A4 inhibitors with aripiprazole, potential benefits should outweigh the potential risks to the patient.

Other strong inhibitors of CYP3A4, such as itraconazole and HIV protease inhibitors may be expected to have similar effects and similar dose reductions should, therefore, be applied see section 4.

Upon discontinuation of the CYP2D6 or CYP3A4 inhibitor, the dosage of aripiprazole should be increased to the dose prior to the initiation of the concomitant therapy. When weak inhibitors of CYP3A4 e.

Concomitant administration of Abilify Maintena and other inducers of CYP3A4 such as rifampicin, rifabutin, phenytoin, abilify maintenance uk price, phenobarbital, primidone, efavirenz, abilify maintenance uk price, nevirapine and St.

John's Wort may be expected to have similar effects. The concomitant use abilify CYP3A4 inducers with Abilify Maintena should be avoided because the blood levels of aripiprazole are decreased and may be below the effective levels. Valproate and maintenance When either valproate or lithium was administered concomitantly with aripiprazole, there was no clinically significant change in aripiprazole concentrations, and, therefore, no dose adjustment is necessary adalat xl 20mg either valproate or lithium is administered with Abilify Maintena.

Additionally, aripiprazole and dehydro-aripiprazole did not price potential for altering CYP1A2-mediated metabolism in vitro. Thus, Abilify Maintena is unlikely to cause clinically important medicinal product interactions mediated by these enzymes. When aripiprazole was administered concomitantly with lamotrigine, dextromethorphan, warfarin, omeprazole, escitalopram, or venlafaxine there was no clinically important change in concentrations of these medicinal products.

Thus, no dosage adjustment of these medicinal products is required when co-administered with Abilify Maintena. Congenital anomalies buy phenergan 25mg online uk been reported; however, causal relationship with aripiprazole could not be established.

Animal studies could not exclude potential developmental toxicity see section 5. Patients must be advised to notify their physician if they become pregnant or intend to become pregnant during treatment with Abilify Maintena.

Due to insufficient maintenance information in humans and prices raised by animal reproductive studies, this medicinal product should not be used in pregnancy unless the expected benefit clearly justifies the potential risk to the foetus.

Prescribers need to be aware of the long-acting properties of Abilify Maintena. There have abilify reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, or feeding disorder. Consequently, new-born infants should be monitored carefully see section 4. Breast-feeding Aripiprazole is excreted in human milk. Fertility Aripiprazole did not impair fertility based on prices from reproductive toxicity studies. Therefore, patients should be advised not to drive or operate machines until their individual susceptibility to this medicinal product is known.

Tabulated list of adverse reactions The incidences of the ADRs associated with aripiprazole therapy are tabulated below. Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness. The frequency of adverse reactions reported during post-marketing use cannot be determined as they are derived from spontaneous reports.

Consequently, abilify maintenance uk price, the frequency of these adverse events is qualified as "not known".