Timolol maleate 5mg

This may augment the risk of general anesthesia in surgical procedures. Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anesthesia. Difficulty in restarting and maintaining the heartbeat has also been reported.

For these reasons, in patients undergoing elective surgery, some authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents. If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists.

Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients especially those with labile diabetes who are receiving insulin or oral hypoglycemic agents. Beta-adrenergic receptor blocking agents may mask the signs and symptoms of acute hypoglycemia.

Thyrotoxicosis Beta-adrenergic blocking agents may mask certain clinical signs e. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm. If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapy with timolol, alternative therapy should be considered. There have been reports of bacterial keratitis associated with the use of multiple dose containers of topical ophthalmic products.

These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epithelial surface. Choroidal detachment after filtration procedures has been reported with the administration of aqueous suppressant therapy e. In patients with angle-closure glaucoma, the immediate objective of treatment is to reopen the angle. This requires constricting the pupil. Your doctor may change the number of tablets you take.

This will depend on how well you respond to the treatment. Do not alter the number of tablets you are taking without checking with your doctor. If you take more Timolol maleate than you should If you or anybody else accidentally take more than the recommended dose of these tablets, call your doctor immediately or go to your nearest hospital casualty department.

If you forget to take Timolol maleate If you forget to take your tablet s , take the next dose as normal. Do not take a double dose to make up for a forgotten dose. If you stop taking Timolol maleate Do not stop taking the tablets without first consulting your doctor. Major Surgery The necessity or desirability of withdrawal of beta-blocking therapy prior to major surgery is controversial.

Beta-adrenergic receptor blockade impairs the ability of the heart to respond to beta-adrenergically mediated reflex stimuli. This may augment the risk of general anesthesia in surgical procedures. Some patients receiving beta-adrenergic receptor blocking agents have been subject to protracted severe hypotension during anesthesia. Difficulty in restarting and maintaining the heartbeat has also been reported. For these reasons, in patients undergoing elective surgery, some authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents.

Diabetes Mellitus Timolol should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients especially those with labile diabetes who are receiving insulin or oral hypoglycemic agents. Beta-adrenergic receptor blocking agents may mask the signs and symptoms of acute hypoglycemia.

Thyrotoxicosis Beta-adrenergic blockade may mask certain clinical signs e. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-blockade which might precipitate a thyroid storm. Dosing in the Presence of Marked Renal Failure Although the pharmacokinetics of Timolol are not greatly altered by renal impairment, marked hypotensive responses have been seen in patients with marked renal impairment undergoing dialysis after 20 mg doses.

Dosing in such patients should therefore be especially cautious. Muscle Weakness Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms e. Timolol has been reported rarely to increase muscle weakness in some patients with myasthenia gravis or myasthenic symptoms. Cerebrovascular Insufficiency Because of potential effects of beta-adrenergic blocking agents relative to blood pressure and pulse, these agents should be used with caution in patients with cerebrovascular insufficiency.

If signs or symptoms suggesting reduced cerebral blood flow are observed, consideration should be given to discontinuing these agents. Non-Steroidal Anti-Inflammatory Drugs Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal anti-inflammatory drugs has been reported. When using these agents concomitantly, patients should be observed carefully to confirm that the desired therapeutic effect has been obtained.

Calcium Antagonists Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function. Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.

Hypotension was more likely to occur if the calcium antagonist were a dihydropyridine derivative, e. Intravenous calcium antagonists should be used with caution in patients receiving beta-adrenergic blocking agents.

Digitalis and Either Diltiazem or Verapamil The concomitant use of beta-adrenergic blocking agents with digitalis and either diltiazem or verapamil may have additive effects in prolonging AV conduction time. Quinidine Potentiated systemic beta-blockade e. Clonidine Beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.

If the two drugs are coadministered, the beta-adrenergic blocking agent should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta-adrenergic blocking agents should be delayed for several days after clonidine administration has stopped.

Thyrotoxicosis Beta-adrenergic blocking agents may mask certain clinical signs e. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm. If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapy with TIMOPTIC, alternative therapy should be considered. There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products.

Choroidal detachment after filtration procedures has been reported with the administration of aqueous suppressant therapy e. Angle-closure Glaucoma In patients with angle-closure glaucoma , the immediate objective of treatment is to reopen the angle. This requires constricting the pupil. Timolol maleate has little or no effect on the pupil. Anaphylaxis While taking beta-blockers, patients with a history of atopy or a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenge with such allergens.

Such patients may be unresponsive to the usual doses of epinephrine used to treat anaphylactic reactions. Muscle Weakness Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms e. Timolol has been reported rarely to increase muscle weakness in some patients with myasthenia gravis or myasthenic symptoms.

Timolol Maleate 5mg Medication

Diabetes Mellitus Maleate blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients especially those with labile diabetes who are receiving insulin or oral hypoglycemic agents. Dosage adjustment to achieve optimal antihypertensive effect may require a few weeks. Obstructive Pulmonary Disease Patients with chronic obstructive pulmonary disease e. If cardiac failure persists, therapy with Timolol maleate should be withdrawn. Beta-adrenergic receptor blockade impairs the ability of the heart to respond to beta-adrenergically mediated reflex stimuli. Timolol maleate 10 mg tablets are not suitable for children. The magnitude of this decreased response is proportional to the existing sympathetic tone and the concentration of Timolol at receptor timolol. Most adverse timolol have been mild and transient, timolol maleate 5mg. Reproduction and fertility studies in rats showed no adverse effect on male or female fertility at doses 5mg to times1 the maximum recommended human dose. If signs or maleate suggesting reduced cerebral blood flow are observed, timolol maleate 5mg, consideration should be 5mg to discontinuing these maleate. Warnings Cardiac Failure Sympathetic stimulation may be essential for support of the circulation in individuals with diminished myocardial contractility, timolol its inhibition 5mg beta-adrenergic receptor blockade may precipitate more severe failure. Your doctor may change the number of tablets you take.

Glaucoma Drugs - Timolol, Betaxolol, Carteolol - Beta Blockers

TIMOLOL MALEATE 10 MG TABLETS

Similar differences were not observed in rats administered oral doses equivalent to approximately 14, times the maximum recommended human ophthalmic dose. Obstructive Pulmonary Disease Patients with chronic obstructive pulmonary disease e. If you take more Timolol maleate than you should If you or anybody else accidentally take more than timolol recommended dose of these tablets, call your doctor immediately or go to your nearest hospital casualty department. The mean peak plasma concentration 5mg morning dosing was 0. Timolol decreases the positive chronotropic, positive inotropic, bronchodilator, and vasodilator responses caused by beta-adrenergic receptor agonists. Nursing Mothers Timolol maleate has been detected in human milk following oral and ophthalmic drug administration. The magnitude of this maleate response is proportional timolol the 5mg sympathetic tone and the concentration of Timolol at receptor sites, timolol maleate 5mg. Quinidine Potentiated systemic beta-blockade e, timolol maleate 5mg. Beta-adrenergic receptor blockade impairs the ability of the heart to respond to betaadrenergically mediated reflex stimuli. Choroidal detachment after filtration procedures has 5mg reported with the administration of aqueous suppressant therapy e. Maleate you should be careful if you are going to drive or operate machinery, timolol maleate 5mg. Both digitalis and Timolol maleate slow AV conduction, timolol maleate 5mg. Furthermore, in adult maleate female subjects who received oral dosages of up to 60 mg of timolol maleate the maximum recommended human oral dosagethere were no clinically meaningful changes in serum prolactin. Patients suspected of timolol thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-adrenergic blocking agents that might precipitate a thyroid storm.

Using Eye Drops to Treat Glaucoma

Mylan Worldwide

timolol maleate 5mg Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients with heart disease. The concomitant use of two topical beta-adrenergic blocking agents is not recommended. Pharmacodynamics Clinical pharmacology studies have confirmed the beta-adrenergic blocking activity as shown by 1 changes in resting heart rate and response of heart rate to changes in posture; 2 inhibition of isoproterenol-induced tachycardia; 3 alteration of the response to the Valsalva maneuver and amyl nitrite administration; and 4 reduction of heart rate and blood pressure changes on exercise. Increased fetal resorptions were also seen in rabbits at doses of 14, times the systemic exposure following the maximum recommended human ophthalmic dose, in this case without apparent maternotoxicity. While taking beta-blockers, patients with a history of atopy or a history of severe anaphylactic reactions to a buying ibuprofen japan of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenge with maleate allergens, timolol maleate 5mg. If it is right for you to stop taking the medicine then your doctor will probably reduce the dose gradually since it is important not to stop suddenly. In Patients Without a History of Cardiac Failure continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. The mechanism of the protective effect of Timolol is unknown, timolol maleate 5mg. Difficulty in 5mg and maintaining the heartbeat has also been reported.

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