Other conditions If you have certain health conditions, taking Vicodin or Percocet could increase certain risks. Before taking Vicodin or Percocet, be sure to tell your doctor if you have constipation or intestinal blockage.
Opioid analgesics can cause increased constipation, so ask your doctor if you should avoid taking them. Alcohol You should not drink alcohol while taking either Vicodin or Percocet. Combining alcohol and these painkillers can cause extreme dizziness or drowsiness, and can even be deadly.
In some cases, taking one of these drugs with alcohol can cause liver damage. This is true if you drink more than three alcoholic drinks per day, have alcoholic liver disease, or have a history of alcohol abuse.
Talk with your doctor Vicodin and Percocet are opioid pain medications that are similar in many ways. Some of the main ways in which they differ are strengths and cost. If your doctor feels you need Vicodin or Percocet for your pain, they will choose the drug for you based on several factors. These factors include your health history and how your body has reacted to pain medications in the past.
Oxycodone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing PERCOCET tablets in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain.
Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product. Elderly and debilitated patients are at particular risk for respiratory depression as are non-tolerant patients given large initial doses of oxycodone or when oxycodone is given in conjunction with other agents that depress respiration. Oxycodone should be used with extreme caution in patients with acute asthma, chronic obstructive pulmonary disorder COPD , cor pulmonale, or preexisting respiratory impairment.
In such patients, even usual therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose. Head Injury and Increased Intracranial Pressure The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure.
Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries. Hypotensive Effect Oxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines.
Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure.
Oxycodone may produce orthostatic hypotension in ambulatory patients. Hepatotoxicity Precaution should be taken in patients with liver disease. Hepatotoxicity and severe hepatic failure occurred in chronic alcoholics following therapeutic doses.
PERCOCET tablets should be given with caution to patients with CNS depression, elderly or debilitated patients, patients with severe impairment of hepatic, pulmonary, or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, urethral stricture, acute alcoholism, delirium tremens, kyphoscoliosis with respiratory depression, myxedema, and toxic psychosis.
Oxycodone may aggravate convulsions in patients with convulsive disorders, and all opioids may induce or aggravate seizures in some clinical settings.
Following administration of PERCOCET tablets, anaphylactic reactions have been reported in patients with a known hypersensitivity to codeine, a compound with a structure similar to morphine and oxycodone. The frequency of this possible cross-sensitivity is unknown.
When such combined therapy is contemplated, the dose of one or both agents should be reduced. Ambulatory Surgery and Postoperative Use Oxycodone and other morphine-like opioids have been shown to decrease bowel motility. Ileus is a common postoperative complication, especially after intra-abdominal surgery with use of opioid analgesia.
Caution should be taken to monitor for decreased bowel motility in postoperative patients receiving opioids. Standard supportive therapy should be implemented. Opioids like oxycodone may cause increases in the serum amylase level.
Tolerance and Physical Dependence Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors.
Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and tolerance are not unusual during chronic opioid therapy. Following administration of PERCOCET tablets, anaphylactic reactions have been reported in patients with a known hypersensitivity to codeine, a compound with a structure similar to morphine and oxycodone.
The frequency of this possible cross-sensitivity is unknown. Ambulatory Surgery and Postoperative Use Oxycodone and other morphine-like opioids have been shown to decrease bowel motility.
Ileus is a common postoperative complication, especially after intra-abdominal surgery with use of opioid analgesia. Caution should be taken to monitor for decreased bowel motility in postoperative patients receiving opioids. Standard supportive therapy should be implemented.
Opioids like oxycodone may cause increases in the serum amylase level. Tolerance and Physical Dependence Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors. Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist.
Physical dependence and tolerance are not unusual during chronic opioid therapy. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: Other symptoms also may develop, including: Laboratory Tests Although oxycodone may cross-react with some drug urine tests, no available studies were found which determined the duration of detectability of oxycodone in urine drug screens.
However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure. Urine testing for opiates may be performed to determine illicit drug use and for medical reasons such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug rehabilitation efforts.
The preliminary identification of opiates in urine involves the use of an immunoassay screening and thin-layer chromatography TLC. The identities of 6-keto opiates e. Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis Animal studies to evaluate the carcinogenic potential of oxycodone and acetaminophen have not been performed.
Mutagenesis The combination of oxycodone and acetaminophen has not been evaluated for mutagenicity. Oxycodone alone was negative in a bacterial reverse mutation assay Ames , an in vitro chromosome aberration assay with human lymphocytes without metabolic activation and an in vivo mouse micronucleus assay.
Oxycodone was clastogenic in the human lymphocyte chromosomal assay in the presence of metabolic activation and in the mouse lymphoma assay with or without metabolic activation. Fertility Animal studies to evaluate the effects of oxycodone on fertility have not been performed.
PERCOCET should not be given to a pregnant woman unless in the judgment of the physician, the potential benefits outweigh the possible hazards. Nonteratogenic Effects Opioids can cross the placental barrier and have the potential to cause neonatal respiratory depression. Opioid use during pregnancy may result in a physically drug-dependent fetus.
After birth, the neonate may suffer severe withdrawal symptoms. Labor and Delivery PERCOCET tablets are not recommended for use in women during and immediately prior to labor and delivery due to its potential effects on respiratory function in the newborn. Acetaminophen is also excreted in breast milk in low concentrations. Pediatric Use Safety and effectiveness in pediatric patients have not been established.
Geriatric Use Special precaution should be given when determining the dosing amount and frequency of PERCOCET tablets for geriatric patients, since clearance of oxycodone may be slightly reduced in this patient population when compared to younger patients. Hepatic Impairment In a pharmacokinetic study of oxycodone in patients with end-stage liver disease, oxycodone plasma clearance decreased and the elimination half-life increased. Care should be exercised when oxycodone is used in patients with hepatic impairment.
Renal Impairment In a study of patients with end stage renal impairment, mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance. Oxycodone should be used with caution in patients with renal impairment. Signs and Symptoms Toxicity from oxycodone poisoning includes the opioid triad of: In severe overdosage, apnea , circulatory collapse, cardiac arrest, and death may occur.
Renal tubular necrosis, hypoglycemic coma, and coagulation defects may also occur. Early symptoms following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. Treatment A single or multiple drug overdose with oxycodone and acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended.
Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Assisted or controlled ventilation should also be considered. Oxycodone Primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and the institution of assisted or controlled ventilation.
The opioid antagonist naloxone hydrochloride is a specific antidote against respiratory depression which may result from overdosage or unusual sensitivity to opioids, including oxycodone.
Since the duration of action of oxycodone may exceed that of the antagonist, the patient should be kept under continued surveillance, and repeated doses of the antagonist should be administered as needed to maintain adequate respiration. An opioid antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Acetaminophen Gastric decontamination with activated charcoal should be administered just prior to N-acetylcysteine NAC to decrease systemic absorption if acetaminophen ingestion is known or suspected to have occurred within a few hours of presentation.
Serum acetaminophen levels should be obtained immediately if the patient presents 4 hours or more after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading.
In this case, abrupt discontinuation of the opioid may result in a withdrawal syndrome. Opioid hydrochloride is relatively rare in patients with chronic pain but may be more common in individuals who have a past hydrochloride of accutane 40mg 5 months or substance abuse or dependence. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive percocet. Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis Animal studies to evaluate the carcinogenic potential of oxycodone and acetaminophen have not been performed. For this reason, doctors are cautious when prescribing them. After birth, the neonate may suffer severe withdrawal symptoms. Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated, oxycodone hydrochloride 5mg vs percocet. The concurrent use of anticholinergics with opioids may produce paralytic ileus. Acetaminophen is oxycodone excreted oxycodone breast milk in low concentrations. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: Care should be exercised when oxycodone is used in patients with hepatic impairment. Reduces acetaminophen absorption when administered as 5mg as possible after overdose. Therefore, the pharmacologic effects of acetaminophen may percocet increased. The concurrent use of anticholinergics with opioids may produce paralytic ileus, oxycodone hydrochloride 5mg vs percocet. PERCOCET should not be given to 5mg pregnant woman unless in the judgment of the physician, the potential benefits outweigh the possible hazards. Renal tubular necrosis and hypoglycemic coma also may occur. Hepatotoxicity Precaution should be taken in patients with liver disease.
Tags: buy requip 0.25mg cheapest generic cialis no prescription
© Copyright 2017 Oxycodone hydrochloride 5mg vs percocet - Loading site please wait....