Metronidazole 200mg pills
The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis, and post-operative wound infections from which pathogenic anaerobes have been isolated. Urogenital trichomoniasis in the female trichomonal vaginitis and in the male.
Bacterial vaginosis also known as non-specific vaginitis, anaerobic vaginosis or Gardnerella vaginitis. All forms of amoebiasis intestinal and extra-intestinal disease and that of symptomless cyst passers. Anaerobically-infected leg ulcers and pressure sores.
Acute dental infections e. Consideration should be given to official guidance on the appropriate use of antibacterial agents. Metronidazole tablets should be swallowed, without chewing, with half a glassful of water during or after meals. Prophylaxis against anaerobic infection: Chiefly in the context of abdominal especially colorectal and gynaecological surgery.
The duration of a course of metronidazole treatment is about 7 days but it will depend upon the seriousness of the patient's condition as assessed clinically and bacteriologically. Treatment of established anaerobic infection: Duration of treatment is usually 7 days. You should abstain from drinking alcohol for the entire duration of your treatment until two days after you have taken the last tablet.
Some women experience a recurrent bout of bacterial vaginosis several weeks after their treatment. If this happens, you may need to complete another course of treatment. If your symptoms return, speak to you doctor. Who can take metronidazole tablets? Metronidazole Tablets Flagyl — Dosage The recommended adult dosage of Flagyl tablets Metronidazole for certain indications is given below.
Please consult your doctor for exact dosing instructions. One-day treatment - two grams of Flagyl, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment - mg three times daily for seven consecutive days. To prevent reinfection the consort should receive a similar course or treatment concurrently.
Plasma concentrations of metronidazole are proportional to the administered dose. Studies reveal no significant bioavailability differences between males and females; however, because of weight differences, the resulting plasma levels in males are generally lower. Distribution Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present.
Metronidazole appears in cerebrospinal fluid , saliva , and breast milk in concentrations similar to those found in plasma. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses. Both the parent compound and the hydroxyl metabolite possess in vitro antimicrobial activity. The average elimination halflife of metronidazole in healthy subjects is eight hours.
Renal Impairment Decreased renal function does not alter the singledose-pharmacokinetics of metronidazole. Effect Of Dialysis Following a single intravenous infusion or oral dose of metronidazole mg, the clearance of metronidazole was investigated in ESRD subjects undergoing hemodialysis or continuous ambulatory peritoneal dialysis CAPD. A peritoneal dialysis session lasting for 7. There were no significant changes in the AUC24 of hydroxylmetronidazole in these hepatically impaired patients. No dosage adjustment is needed for patients with mild to moderate hepatic impairment.
Pediatric Patients In one study, newborn infants appeared to demonstrate diminished capacity to eliminate metronidazole. The elimination halflife, measured during the first 3 days of life, was inversely related to gestational age. In infants whose gestational ages were between 28 and 40 weeks, the corresponding elimination halflives ranged from to Microbiology Mechanism Of Action Metronidazole, a nitroimidazole, exerts antibacterial effects in an anaerobic environment against most obligate anaerobes.
As with all medicines, metronidazole may cause unwanted effects in some people, although serious reactions are rare. An unpleasant taste in the mouth, furred tongue, nausea, vomiting or other gastro-intestinal disturbance has been reported. Occasionally, you may feel drowsy, dizzy, have a headache and feel shaky or unsteady while taking metronidazole.
Hypersensitivity reaction can occur including skin rashes, including nettle rash, or itching.
Flagyl By Abbott (original Brand)
Drug Resistance A potential for development of resistance exists against metronidazole. Renal Impairment Patients with end-stage renal disease may excrete metronidazole and metabolites slowly in the urine, resulting in significant accumulation of metronidazole metabolites. Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently. Metronidazole cause and effect relationship has not been established, metronidazole 200mg pills. Bactericidal concentrations of metronidazole have also been detected in pus 200mg hepatic abscesses. The precise mechanism metronidazole action of metronidazole is unclear, metronidazole 200mg pills. Duration of treatment is usually 7 days. Due to inadequate evidence on the 200mg risk in humans see section 5. There have been some reports in the medical literature of breast and colon cancer in Crohn's disease patients who have been treated with metronidazole at pill doses for extended periods of time, metronidazole 200mg pills. Delivery options may vary depending on the pack size and dosage chosen. Prothrombin times should be monitored. Metronidazole reduces the clearance of 5 fluorouracil and can therefore pill in increased toxicity of 5 fluorouracil.
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