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Metronidazole is a powerful antibiotic medication. Therefore, it is an ideal drug for treatment involving diverse bacterial infections and diseases.

Thus, if confronted with a bacterial-related infection, there is the highest chance that treatment will occur when taking Flagyl compared with any other antibiotic drug.

Bacterial infections related to organ systems such as the stomach, vagina, respiratory tract, and joints and skin can be effectively treated with Flagyl. This pharmacotherapy is also recommended for the treatment of other high-risk infections such as bacterial vaginosis , amebiasis, dracunculiasis, trichomoniasis , and giardiasis.

If a patient is in the early stages of Clostridium difficile colitis Flagyl can provide the initial necessary treatment. Flagyl, when paired with other antibiotic medications, is an effective treatment for bacterial vaginosis, pelvic inflammatory disease, and endocarditis. Flagyl is offered in several forms and dosages. When undergoing treatment with Flagyl, this medication should only be taken as prescribed by a physician.

Metronidazole Tablets — Dosage The recommended adult dosage of Flagyl tablets for certain indications is given below. The dosage of Flagyl should be individualized. Please consult your doctor for exact dosing instructions. One-day treatment - two grams of Flagyl, given either as a single dose or in two divided doses of one gram each, given in the same day.

Seven-day course of treatment - mg three times daily for seven consecutive days. For acute intestinal amebiasis acute amebic dysentery: For amebic liver abscess: As this medication is used for different treatments, please consult your doctor and follow given recommendation. Warnings And Precautions When Using Flagyl Tablets Before using Flagyl Tablets please inform your doctor all the medicines that you take including no prescription medications, over the counter medicines and herbal remedies.

Lithium In patients stabilized on relatively high doses of lithium , short-term metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity.

Serum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication.

Busulfan Metronidazole has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Metronidazole should not be administered concomitantly with busulfan unless the benefit outweighs the risk.

If no therapeutic alternatives to metronidazole are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly. Drugs That Inhibit CYP Enzymes The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine , may prolong the half-life and decrease plasma clearance of metronidazole.

Drugs That Induce CYP Enzymes The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital , may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide NAD- NADH.

Interference is due to the similarity in absorbance peaks of NADH nm and metronidazole nm at pH 7. Encephalopathy has been reported in association with cerebellar toxicity characterized by ataxia , dizziness, and dysarthria. CNS symptoms are generally reversible within days to weeks upon discontinuation of metronidazole.

Peripheral neuropathy, mainly of sensory type has been reported and is characterized by numbness or paresthesia of an extremity. Convulsive seizures have been reported in patients treated with metronidazole. Aseptic meningitis Cases of aseptic meningitis have been reported with metronidazole. Symptoms can occur within hours of dose administration and generally resolve after metronidazole therapy is discontinued.

If you buy any medicines, check with a pharmacist that they are safe to take with metronidazole. Some cough and cold preparations contain alcohol and should not be taken with metronidazole. If you need to take metronidazole for longer than ten days, your doctor may want you to have some tests. Make sure you keep any appointments that your doctor gives to you. Can metronidazole cause problems? Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them.

The table below contains some of the ones associated with metronidazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine.

The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Metronidazole side-effects What can I do if I experience this? Feeling sick nausea or being sick vomiting Stick to simple foods. Make sure you take your doses after a meal or a snack Changes in the way things taste, furred tongue, sore mouth Ask your pharmacist to recommend a suitable mouthwash Lack of appetite This should soon pass, but in the meantime choose food that you usually enjoy If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store metronidazole Keep all medicines out of the reach and sight of children. Dosage of the latter may require reducing. Prothrombin times should be monitored. There is no interaction with heparin.

Lithium retention accompanied by evidence of possible renal damage has been reported in patients treated simultaneously with lithium and metronidazole.

Lithium treatment should be tapered or withdrawn before administering metronidazole. Plasma concentrations of lithium, creatinine and electrolytes should be monitored in patients under treatment with lithium while they receive metronidazole. Patients receiving phenobarbital or phenytoin metabolise metronidazole at a much greater rate than normally, reducing the half-life to approximately 3 hours. Metronidazole reduces the clearance of 5 fluorouracil and can therefore result in increased toxicity of 5 fluorouracil.

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