Emergency help should be sought in cases where an anaphylactoid reaction occurs. These serious events may occur without warning. Patients should be informed about the signs and symptoms of serious skin manifestations, and the use of the drug should be discontinued at the first appearance of skin rash or any other signs of hypersensitivity.

Diclofenac sodium topical gel should not be applied to open skin wounds, infections, inflammations, or exfoliative dermatitis, as it may affect absorption and tolerability of the drug. Diclofenac sodium topical gel should not be allowed to come into contact with the eyes or with mucous membranes.

The effect of diclofenac sodium topical gel under occlusive dressings has not been evaluated, and should be avoided. Pregnancy As with other NSAIDs, diclofenac sodium topical gel should be avoided in late pregnancy, because it may cause premature closure of the ductus arteriosus. Corticosteroid treatment Diclofenac sodium topical gel cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency.

Abrupt discontinuation of corticosteroids may lead to exacerbation of corticosteroid-responsive illness. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids.

Inflammation The pharmacological activity of diclofenac in reducing inflammation, and possibly fever, may diminish the utility of these diagnostic signs in detecting infectious complications of presumed noninfectious, painful conditions.

This may be due to fluid retention, occult or gross GI blood loss, or an incompletely described effect upon erythropoeisis. Patients on long-term treatment with NSAIDs, including diclofenac sodium topical gel, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia or blood loss. NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. Unlike aspirin, their effect on platelet function is quantitatively less, of shorter duration, and reversible.

Patients treated with diclofenac sodium topical gel who may be adversely affected by alteration in platelet function, such as those with coagulation disorders or patients receiving anticoagulants should be carefully monitored. Preexisting Asthma Patients with asthma may have aspirin-sensitive asthma. The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm, which can be fatal. Since cross reactivity, including bronchospasm, between aspirin and other non-steroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, diclofenac sodium topical gel should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.

Sun Exposure Patients should minimize or avoid exposure to natural or artificial sunlight on treated areas because studies in animals indicated topical diclofenac treatment resulted in an earlier onset of ultraviolet light induced skin tumors. The potential effects of diclofenac sodium topical gel on skin response to ultraviolet damage in humans are not known. Eye Exposure Contact of Diclofenac sodium topical gel with eyes and mucosa, although not studied, should be avoided.

Patients should be advised that if eye contact occurs, they should immediately wash out the eye with water or saline and consult a physician if irritation persists for more than an hour.

Laboratory Tests Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding. If abnormal liver tests or renal tests persist or worsen, diclofenac sodium topical gel should be discontinued. Adverse Reactions Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

During clinical development, patients were exposed to diclofenac sodium topical gel in randomized, double-blind, multicenter, vehicle-controlled, parallel-group studies in osteoarthritis of the superficial joints of the extremities. Of these, patients received diclofenac sodium topical gel for osteoarthritis of the knee and were treated for osteoarthritis of the hand. Additionally, patients were exposed to diclofenac sodium topical gel in an uncontrolled, open-label, long-term safety trial in osteoarthritis of the knee.

Of these, patients were treated for osteoarthritis of 1 knee and were treated for osteoarthritis of both knees. Duration of exposure ranged from 8 to 12 weeks for the placebo-controlled studies, and up to 12 months for the open-label safety trial.

Non-serious adverse reactions that were reported during the short-term placebo-controlled studies comparing diclofenac sodium topical gel and placebo vehicle gel over study periods of 8 to 12 weeks 16 g per day , were application site reactions.

The generic name of this drug is Diclofenac topical and the other brand names are Pennsaid and Voltaren Topical. Solaraze gel works by inflammation- and pain-causing hormones in the body.

It contains the active ingredient diclofenac sodium in addition to polyethylene glycol monomethyl ether, hyaluronate sodium, benzyl alcohol, and purified water. This medication is available as 50gm Solaraze gel and gm Solaraze gel tubes. Side effects of Solaraze gel You should not buy Solaraze gel online if: You have allergy to aspirin or other NSAIDs such as ibuprofen, naxproxen and celecoxib You have certain medical conditions Aspirin sensitive asthma Before you buy Solaraze gel, inform your doctor if you have any of the following: Medical history especially of kidney disease Liver disease A bleeding or blood clotting disorder A history of stomach ulcer Some of the common, side effects of this drug are: The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.

Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. In patients who are elderly, volume-depleted including those on diuretic therapy , or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.

These effects are usually reversible. When these drugs are administered concomitantly, patients should be adequately hydrated.

Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics e.

The concomitant use of diclofenac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. NSAIDs with short elimination half-lives e. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives e.

However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses. To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowesteffective dose for the shortest duration possible.

Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk ofserious CV thrombotic events associated with NSAID use. Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative riskof death in NSAID users persisted over at least the next four years of follow-up.

Gastrointestinal Bleeding, Ulceration, And Perforation NSAIDs, including diclofenac, cause serious gastrointestinal GI adverse events including inflammation, bleeding, ulceration , and perforation of the esophagus , stomach, small intestine , or large intestine , which can be fatal.

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Nursing mothers should avoid diclofenac medicine since it passes into breast milk and can harm online nursing baby. Diclofenac the absolute rate of death declined somewhat after online first year diclofenac, the increased relative riskof death in Online users persisted gel at least the next four years of follow-up. This may be due to occult or gross blood loss, fluid retention, or an incompletely described effect on erythropoiesis. Based on clinical trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 weeks after initiating treatment with diclofenac. In case of a missed dose, a patient should apply the gel as soon as he or she diclofenac. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives e, diclofenac gel online. Table 1 lists the types of application site reactions reported. Physicians and patients should remain alert for the development of such events, gel the gel treatment course, diclofenac gel online, even in the absence of previous CV symptoms. Hepatic Effects Elevations online one or more liver tests may occur during therapy gel diclofenac sodium.

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Solaraze Gel (Diclofenac Sodium)

Laboratory Monitoring Because serious GI bleeding, hepatotoxicity, and renal injury can occur without warning symptoms or signs, consider monitoring patients on long-term NSAID treatment with a CBC anda chemistry profile periodically. Drinking alcohol should gel totally avoided since it could lead to stomach bleeding. These serious events may occur without warning. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur. Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosisjaundicefulminant hepatitis with and without jaundice, and liver failure, diclofenac gel online. There is no consistent evidence that concurrent use of aspirin flutamide tablets 250mg the increased risk ofserious CV thrombotic events associated with NSAID use. Of these, diclofenac gel online, patients received diclofenac sodium topical gel for osteoarthritis of the knee and were treated for osteoarthritis of the hand. These trends continue with longer duration of use, increasing the likelihood of developing a serious GI event at some time diclofenac the course of therapy. The 2 g line is 2. Sun Exposure Online should minimize or avoid exposure to natural or artificial sunlight on treated areas because studies in animals indicated topical diclofenac treatment resulted in an earlier onset ofultraviolet light induced skin tumors. NSAIDs have produced elevations online plasma lithium levels and reductions in renal lithium clearance. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur e. These serious events diclofenac occur without warning. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal gel.

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You have allergy to aspirin or other NSAIDs such as ibuprofen, naxproxen and celecoxib You have certain medical conditions Aspirin sensitive asthma Before you buy Solaraze gel, diclofenac gel online, gel your doctor if you have any of the following: Renal toxicity has also been seen in patients in whom renal prostaglandins have a diclofenac role in the maintenance of renal perfusion, diclofenac gel online. Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac, because severe hepatotoxicity may develop gel a prodrome online distinguishing symptoms. Application site reactions, including application site dermatitis, diclofenac gel online, were the most frequent reason for treatment discontinuation, diclofenac gel online. NSAIDs, including diclofenac sodium topical gel should be used with caution gel patients with online. You can continue with your regular schedule if it is already diclofenac for your next online of diclofenac medicine. Some of these reported cases resulted in fatalities or liver transplantation. Diclofenac sodium topical gel should be used with caution in patients with fluid retention or heart failure. The concomitant use of diclofenac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

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