Diclofenac 60mg

Diclofenac is given to treat painful conditions such as arthritis , sprains and strains , gout , migraine , dental pain , and pain after surgical operations. It eases pain and reduces inflammation. Diclofenac is available on prescription. Diclofenac works by blocking the effect of chemicals in your body, called cyclo-oxygenase COX enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Prostaglandins are produced at sites of injury or damage, and cause pain and inflammation.

By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased. There are two forms of diclofenac - diclofenac sodium and diclofenac potassium. The main difference between the two is that diclofenac potassium is absorbed into the body more quickly than diclofenac sodium.

A quick action is useful where immediate pain relief is required, and a prolonged action is more useful in reducing inflammation. Some brands of diclofenac also contain a medicine called misoprostol. Misoprostol helps to protect the stomach against irritation which can be caused by taking diclofenac over a period of time. Diclofenac is not a suitable medicine for people who have heart disease such as heart failure , or who have circulatory problems, or who have had a heart attack or a stroke.

This is because it has been found that there is a small increased risk of heart attack and stroke in this group of people. Other anti-inflammatory medicines are more suitable for people with these conditions - ask your doctor or pharmacist for advice about an alternative medicine. Diclofenac is also formulated as skin gels, patches and as eye drops. Before taking diclofenac Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken.

For these reasons, before you start taking your diclofenac dosage, it is important that your doctor knows: It may harm them, even if their signs of illness are the same as yours. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. In this leaflet 1. Possible side effects 5. Contents of the pack and other information 1. NSAIDs reduce pain and inflammation. Rheumatoid arthritis, osteoarthritis, acute gout painful inflammation of the joints especially in the feet and hands , ankylosing spondylitis form of spinal arthritis.

Backache, sprains and strains, soft tissue sports injuries, frozen shoulder, dislocations and fractures Conditions affecting the tendons for example, tendonitis, tenosynovitis, bursitis. They are also used to treat pain and inflammation associated with dental and minor surgery. Signs of a hypersensitivity reaction include swelling of the face and mouth angioedema , breathing problems, runny nose, skin rash or any other allergic type reaction.

If you do, your doctor may ask you to go for regular check-ups while you are taking these tablets. Children These tablets are not suitable for children aged under Please tell your doctor or pharmacist if you are taking any of the following: Medicines to treat diabetes Anticoagulants blood thinning tablets like warfarin Diuretics water tablets Lithium used to treat some mental problems Methotrexate for treatment of some inflammatory diseases and some cancers Ciclosporin and tacrolimus used to treat some inflammatory diseases and after transplants Trimethoprim a medicine used to prevent or treat urinary tract infections Quinolone antibiotics for infections Any other NSAID or COX-2 cyclo-oxygenase-2 inhibitor, for example aspirin or ibuprofen Mifepristone a medicine used to terminate pregnancy Cardiac glycosides for example digoxin , used to treat heart problems Medicines known as SSRIs used to treat depression Oral steroids an anti-inflammatory drug Medicines used to treat heart conditions or high blood pressure, for example beta blockers or ACE inhibitors Voriconazole a medicine used to treat fungal infections.

This means medicines you have bought yourself as well as medicines on prescription from your doctor. Diclofenac Sodium 50MG with food and drink Take this medicine with or after food. Pregnancy and breast-feeding Although not common, abnormalities have been reported in babies whose mothers have taken NSAIDs during pregnancy.

You should advise your doctor or pharmacist if you think you might be pregnant or are up to 6 months pregnant. Taking Diclofenac Sodium 50MG tablets may make it more difficult to become pregnant.

You should talk to your doctor if you are planning to become pregnant, or if you have problems getting pregnant. You should avoid taking Diclofenac Sodium whilst breast feeding. Driving and using machines Very occasionally people have reported that diclofenac sodium tablets have made them feel dizzy, tired or sleepy.

Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.

Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.

In patients who are elderly, volume-depleted including those on diuretic therapy , or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.

These effects are usually reversible. When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics e.

The concomitant use of diclofenac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.

NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. NSAIDs with short elimination half-lives e. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives e. Co-administration of diclofenac with CYP2C9 inhibitors e.

However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses. To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible.

Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms.

Patients should be informed about the symptoms of serious CV events and the steps to take if they occur. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up.

Gastrointestinal Bleeding, Ulceration, And Perforation NSAIDs, including diclofenac, cause serious gastrointestinal GI adverse events including inflammation, bleeding, ulceration , and perforation of the esophagus , stomach, small intestine , or large intestine , which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. This medication may make you more sensitive to the sun.

Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Before using this medication, women of childbearing age should talk with their doctor s about the benefits and risks such as miscarriage , trouble getting pregnant. Tell your doctor if you are pregnant or if you plan to become pregnant.

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