Your dose will depend on your needs and medical condition: Operations or tests If you are due to have an operation, tell your doctor you are taking Danazol. This is because Danazol can increase the effect of some anaesthetics. Normally you will need to take Danazol for 6 months, but you may have to take it for up to 9 months. Check with your doctor or pharmacist if you are not sure. If your endometriosis is severe, or if your bleeding continues after 2 months of treatment, your doctor may give you a higher dose.
Before an operation for endometriosis, the recommended dose is mg to mg daily for 3 to 6 weeks. Cyclomen Storage Cyclomen Warnings Before taking Cyclomen Danazol mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details. Before using Cyclomen Danazol mg, tell your doctor or pharmacist your medical history, especially of: Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products.
Cyclomen Danazol mg may affect the sperm. Consult your doctor for more details. Cyclomen Danazol mg must not be used during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away. It is unknown if Cyclomen Danazol mg passes into breast milk. Because of the possible risk to the infant, breast-feeding while using Cyclomen Danazol mg is not recommended.
Consult your doctor before breast-feeding. Store at room temperature away from light and moisture. Hepatic dysfunction, as evidenced by reversible elevated serum enzymes has been reported. Jaundice has been reported rarely. It is recommended that patients receiving danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation see Precautions.
Rare occurrences of benign hepatic adenomata, malignant hepatic tumor and peliosis hepatis have also been observed with long-term use. Rare cases of pancreatitis have been reported. Although the following reactions have also been reported, a causal relationship to the administration of danazol has neither been confirmed nor refuted: Skin and Mucous Membranes: Symptoms And Treatment Of Overdose: Available evidence suggests that acute overdosage would be unlikely to give rise to immediate serious reaction.
Nonetheless, consideration should be given to removal of the drug by emesis or stomach pump and the patient should be kept under observation in case of any delayed reactions. A reduction in dosage once a satisfactory response has been achieved may prove possible. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on danazol therapy. An effective nonhormonal method of contraception should be used during the complete course of treatment.
Regular menstrual patterns, irregular menstrual patterns and amenorrhea each occur in approximately one-third of patients treated with mg danazol. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses.
Clinical effectiveness has been achieved with total daily doses of danazol ranging from to mg in 2 to 4 divided doses and administered without interruption for 3 to 6 months.
If, at the lower doses, an anovulatory and amenorrheic state is not achieved and if the symptomatology is not relieved in 30 to 60 days, the dose should be increased. In patients with severe presenting symptomatology, the usual starting dose is mg daily.
The maximum recommended daily dose is mg. It is essential that therapy continue uninterrupted for 3 to 6 months, but may be extended to 9 months, if necessary. Shorter courses of therapy have been used as adjuncts to surgery.
After termination of therapy, if symptoms recur, treatment can be reinstated. A course of to mg of danazol daily in divided doses for up to 6 months. If no improvement is observed after 2 or 3 cycles, treatment should be discontinued and the patient should be reassessed for the cause of the excess bleeding. The total daily dose of danazol ranges from to mg in two divided doses depending on patient response.
Pain and tenderness usually respond to treatment after 30 to 40 days. Nodularity usually does not begin to regress until 60 to 90 days after initiation of therapy. Treatment should continue uninterrupted until complete disappearance of symptoms or for 6 months, whichever occurs first. In this event, treatment may be reinstated.
If you experience migraine headaches, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Danazol may increase the risk of ovarian cancer in people treated for endometriosis. Danazol may affect medications taken to control seizures. If you have epilepsy or another seizure disorder, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Danazol may interfere with laboratory tests used to monitor thyroid function. If taken during pregnancy, danazol may be harmful to the unborn child.
Danazol should be started during menstruation and an effective nonhormonal method of birth control should be used while taking it. If you think you may be pregnant, stop taking danazol and discuss the risks with your doctor. Danazol may cause harm to an infant if it is taken by a breast-feeding mother. It must not be taken by women who are breast-feeding. The safety and effectiveness of this medication have not been established for use by children.
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