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Gutted they don't sell this stuff anymore. Makes life a misery when you can feel an Ulcer coming on and there's nothing you can do to stop it Jamie 11 August 10 Hey! Have just found Trinolone on ebay and no restriction on quantities it seems. Originates from Thailand but seems to come from Au site http: Is also available in Israel across counter as a friend brought me 2 tubes when visiting Chris 21 July 10 I have just purchased some Trinolone Oral Paste, in Thailand from a pharmacy, ingredients: Triamcinolone Acetonide in Dental Paste.

This appears to be the same as Adcortyl, although I have yet to try it I am still squeezing the last out of the Adcortyl tube. When I do use it I will post. PS It cost baht approx. My in laws live in Barbados so I can get them to bring some over when they come next month.

Does it really have the same active ingredient? Many thanks Jo 11 June 10 It's about 4. Frances 23 May 10 Hi Found this info really helpful have been using Adcortyl for years! I have just ordered some kenalog from NZ i hope it is as good as Adcortyl. Nicky 13 May 10 Hi It is very difficult to get Kenalog without a prescription.

Find a friend there to ship it for you as it is cheaper than tubes from New Zealand. Chris 7 May 10 Hi I've been suffering for mouth ulcers all my life and have been using Adcortyl in Orabase for over 10 years. I was worried when it went off the market but I finally found a way to get it. It can be made up specially by 'Cardinal Health' in the UK.

What's more, I got a 30g tube, which is 3x bigger then the tube I could usually get in Ireland 10g and I think it was sold as 5g in the UK. So this should last me a long time. But here is the catch people - it is very expensive. But as we mouth ulcer sufferers know, Adcortyl in Orabase is worth every cent or penny! So yes it is complete extortion but still worth it. This has encouraged me to try natural preventative measures. It seem odd that they would discontinue a product many of us would pay any amount to get.

Neil 4 May 10 Sadly Waltham pharmacy have run out! Have just ordered 2 tubes of Oracort from drugstorechemist. It all seemed very easy so am hopeful delivery will be the same. Will advise when arrive and pray it will be as good as Adcortyl!

Have just tried to survive 2 massive ulcers and ended up taking time off work as pain, glands, and feeling sick really bad! Nothing else recommended by pharmist, doctor or dentist works! Amalou 1 May 10 Cant find Adcortyl on the Waltham pharmacy website! Had to resort to tring the NZ website mentioned at the start of this string. Any news about other manufacturers taking up the manufacture of adcortyl?

Like everyone else, I used to rely on adcortyl and was completely gutted when I was told it was discontinued Marcus 28 April 10 Thank you guys so much for the advise above. Waltham Pharmacy still have stocks as I was able to order successfully 2 tubes this morning.

I am going to check out Hong Kong and will post any further information. I agree with Hilary Feb it is a disgrace to discontinue such a brilliant product on a cost basis, we sufferers would pay anything for the relief it brings. Sue Lane 15 March 15 March 10 got some this morning from waltham 2 tubes ordered sat judy 4 March 10 Hi everyone, I posted this in the big thread but thought I'd it here as well. As per posts above I have recieved adcortyl from waltham, but obviously this source isn't going to last forever.

But here is another possibility for you: I haven't used it in anger yet, but it has the exact same active ingredient as Adcortyl, in the same concentration, in the same carrier gel. I don't think you can get it in the UK, but I successfully recieved an order from Drugstorchemist. It's made in Canada, even has the same expiry date as the final batches of Adortyl - Micky 27 February 10 This site has been so helpful.

Been to local Boots stores and other chemists in West Sussex area. Help I am now sending off for some from Walthfam Pharmacy, here's hoping they have some left in stock! Stocks are limited, so get in while in lasts. Waltham's are based in Grimsby apparently.

Robin H 25 February 10 Thank you David! Suffered for 30 years, getting worse by the year and I was in tears in the pharmacy when they said it had been discontinued. At least this order will help until hopefully they sort out alternative manufacturer. Zoe H 25 February 10 Thank you David. I too have just ordered some from Waltham Pharmacy.

How could Squibbs have been that shortsighted? No wonder this country is in a financial mess. Hilary 22 February 10 Thanks David. I have also just ordered some from Waltham Pharmacy.

Sarah Evans 22 February 10 Thanks David for this info. I have also ordered from Waltham Pharmacy. Glyn King 17 February 10 Just an update: My tubes arrived on Sat and made my weekend.

Best Valentines present ever! David Daley 15 February 10 I think I may have found a pharmacy which still has some in stock! I've ordered a few tubes this morning so fingers crossed it's all legit. I e-mailed and this seems to be true. Was told Your doctor can contact them on The only other product, available from Helios Pharmacy is Myrrh tincture which also helps with healing and pain relief for mouth ulcers.

Janine Parkinson 2 February 10 http: The inner part of her lips get licked, right above clit. Slip well lubricated fingers in and gently move them horizontally and vertically, or in circles. LayaSpot vibrator also available here 3.

This is a highly sensitive patch located on the upper wall of the vagina, cm in from the vaginal opening.

Insert the first two fingers cm inside the vagina. Position the fingers at The woman lies down on a table or bed with many pillows with her back slightly angled.

Her legs are up and slightly toward her breasts. You stand in front of her and enter slowly. Keep the thrusts shallow at first and then go deeper. K or P 2 together, pattern to the end of the row. Pattern to the last 2 stitches, K or P2 together.

Repeat these 2 rows until 4 7,15 stitches remain. Side Tabs Make one tab on each side. Half way between the last increase row and the neck edge mark off the center 2 4, 6 inches. With right side facing pick up and K 11 19, 29 stitches along the center marked edge. Work in K1, P1 pattern until tab measures 2, 2, 4 inches from the side edge.

To shape the tab, K or P 2 together, pattern to the last 2 stitches, K or P 2 together. The other option is for the sponsor to outsource management and conduct of CEC activities. CEC is a very important component of medical device clinical trial. Adjudicated adverse event data is highly regarded by regulatory agencies and the physician community. In many cases, it is a requirement to have adjudicated adverse event data in order to get the product on market. According to IMARC research , the purpose of the DMC is to advise the sponsor on continuing safety of the trial subjects and those yet to be recruited and provide continuing validity and scientific merit of the study.

For budgeting purposes, it is important to know that DSMB is required during trial enrollment phase. The decision of whether or not to conduct DSMB meetings after the primary endpoint is reached, is up to the sponsor. Physician consulting Physicians are consulted during all phases of a clinical trial. Physician guidance is needed to develop clinical trial strategy, enrollment plan, final data analysis and publication plans. If a clinical trial is interesting to the physician, he or she may be willing to provide consulting services at little or no cost.

Independent corelab analysis Many medical device trials collect imaging data such as angiograms, CT scans and X-Rays. Since this data comes from multiple sites, variability is expected. An independent corelab standardizes the collection and analysis of imaging data. Corelab costs can add up quickly.

Costs depend upon the number of images analyzed per patient, the time it takes for the corelab to analyze the data, and the duration of the trial. Corelabs usually hire analysts to collect and calibrate data from different sites. The final analysis is usually done by a physician. Given the complexity of imaging data collection and analysis combined with the importance of corelab data to regulatory agencies, it is important that adequate and accurate budget is allocated for independent corelab analysis.

Most sites will expect to receive these devices for free. The only exception is when conducting post approval trials for commercially available devices. Medical device manufacturers conduct trials for indication expansion. For example, a stent company may conduct a trial to get their heart stent approved for use in a different anatomy.

For such expansion trials, sponsors may need to provide commercially available devices to sites at no cost. Whether or not you want to provide devices at no cost is a business decision.

When investigational medical devices are provided at no cost, sites enroll faster and have a much stronger, collaborative relationship with the sponsor. Labor Costs In order to conduct a clinical trial, you need to hire people that have expertise in clinical research and clinical trial management.

Depending on the size of the trial and the number of trials conducted, resource allocations vary. Therefore amount of labor needed to run a study also varies.

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