As a result, it may precipitate congestive heart failure which worsens with fluid overload in those at risk. It may cause anemia. Mild weight gain is common due to increase in subcutaneous adipose tissue.

In studies, patients on pioglitazone had an increased proportion of upper respiratory tract infection, sinusitis, headache, myalgia and tooth problems. Chronic administration of the drug has led to occasional instances of cholestatic hepatitis , reversible upon drug discontinuation. The risk of fracture should be considered in the care of patients, especially female patients, treated with ACTOS and attention should be given to assessing and maintaining bone health according to current standards of care.

Macular Edema Macular edema has been reported in postmarketing experience in diabetic patients who were taking ACTOS or another thiazolidinedione. Some patients presented with blurred vision or decreased visual acuity , but others were diagnosed on routine ophthalmologic examination. Most patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of the thiazolidinedione.

Patients with diabetes should have regular eye exams by an ophthalmologist according to current standards of care. Macrovascular Outcomes There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with ACTOS. It is important to instruct patients to adhere to dietary instructions and to have blood glucose and glycosylated hemoglobin tested regularly. During periods of stress such as fever, trauma , infection, or surgery, medication requirements may change and patients should be reminded to seek medical advice promptly.

Patients who experience an unusually rapid increase in weight or edema or who develop shortness of breath or other symptoms of heart failure while on ACTOS should immediately report these symptoms to a physician.

Tell patients to promptly stop taking ACTOS and seek immediate medical advice if there is unexplained nausea, vomiting, abdominal pain, fatigue, anorexia, or dark urine as these symptoms may be due to hepatotoxicity.

Tell patients to promptly report any sign of macroscopic hematuria or other symptoms such as dysuria or urinary urgency that develop or increase during treatment as these may be due to bladder cancer.

ACTOS can be taken with or without meals. If a dose is missed on one day, the dose should not be doubled the following day. When using combination therapy with insulin or other antidiabetic medications, the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and their family members.

Inform female patients that treatment with ACTOS, like other thiazolidinediones, may result in an unintended pregnancy in some premenopausal anovulatory females due to its effect on ovulation [see Use In Specific Populations]. Drug-induced tumors were not observed in any organ except for the urinary bladder of male rats. Urinary calculi with subsequent irritation and hyperplasia were postulated as the mechanism for bladder tumors observed in male rats.

A two-year mechanistic study in male rats utilizing dietary acidification to reduce calculi formation was completed in Dietary acidification decreased but did not abolish the hyperplastic changes in the bladder. The presence of calculi exacerbated the hyperplastic response to pioglitazone but was not considered the primary cause of the hyperplastic changes. The relevance to humans of the bladder findings in the male rat cannot be excluded.

Check with your doctor or pharmacist if you are not sure. The usual starting dose is one tablet of 15 mg or of 30 mg of Pioglitazone to be taken once daily. Your doctor may increase the dose to a maximum of 45 mg once a day.

Your doctor will tell you the dose to take. If you have the impression that the effect of Pioglitazone is too weak, talk to your doctor. When Pioglitazone is taken in combination with other medicines used to treat diabetes such as insulin, chlorpropamide, glibenclamide, gliclazide, tolbutamide your doctor will tell you whether you need to take a smaller dose of your medicines.

Your doctor will ask you to have blood tests periodically during treatment with Pioglitazone. This is to check that your liver is working normally. If you are following a diabetic diet, you should continue with this while you are taking Pioglitazone. Your weight should be checked at regular intervals; if your weight increases, inform your doctor. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda.

Tell your doctor right away about the reaction and the use of this product. Symptoms of high blood sugar hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away.

Your dosage may need to be increased. A very serious allergic reaction to this drug is rare.

PIOGLITAZONE 15 MG TABLETS

Tell your doctor right away about the reaction and the use of this product. If you have the impression that the effect of Pioglitazone is too weak, actos 15mg, talk to your doctor. Pioglitazone Side Effects Common Side Effects of Pioglitazone Tell your doctor if any of the following side effects become severe or don't go away: In the two pooled to week add-on to metformin trials, actos 15mg, patients There are insufficient data to determine whether pioglitazone is a tumor promoter for urinary bladder tumors. The risk of fracture should be considered in the care of patients, especially female patients, treated with ACTOS and attention should actos given to assessing and maintaining bone health according to current standards of care. You should know the symptoms of high hyperglycemic or low hypoglycemic blood-sugar episodes and be prepared to treat them. Pioglitazone may cause changes in your blood sugar. Therefore, obtaining a liver test panel serum alanine aminotransferase [ALT], 15mg aminotransferase [AST], alkaline phosphatase, and total bilirubin and assessing the patient is recommended before initiating ACTOS therapy. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

ACTOS 15 (Actos 15 mg)

Patients should be observed for signs and symptoms of congestive heart failure. Pioglitazone is currently being reviewed. Pioglitazone and Bladder Cancer People who took pioglitazone phentermine 15mg does it work more than a year were more likely to develop bladder cancer than those who didn't take the medicine. There are risks to 15mg mother and fetus associated with poorly controlled diabetes actos pregnancy [see Clinical Considerations]. These elevations resolved without any actos clinical sequelae. Inform female patients that treatment with ACTOS, like other thiazolidinediones, may result in an unintended pregnancy in some premenopausal anovulatory females due to its effect on ovulation [see Use In Specific Populations], actos 15mg. How to take Pioglitazone Always actos this medicine exactly as your 15mg or pharmacist has told you. Because thiazolidinediones, including ACTOS, can cause fluid retention, which can exacerbate or lead to congestive heart failure, ACTOS should be used with caution in patients at risk for congestive heart failure, actos 15mg. These changes primarily occurred within the first 4 to 12 weeks of therapy and remained relatively constant thereafter. PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscleand liver. In controlled clinical trials, ACTOS had an additive effect on glycemic control when used in combination with a sulfonylureametforminactos 15mg, or insulin [see Clinical Studies]. Pioglitazone is an agonist for peroxisome proliferator-activated receptor -gamma PPAR? Actos reports of congestive heart failure have been reported in patients treated with ACTOS, both with and without previously known heart disease and both with and without concomitant insulin administration, actos 15mg. The presence of calculi exacerbated the hyperplastic response to pioglitazone but was not considered 15mg primary cause of the hyperplastic changes. Hypoglycemia In the ACTOS clinical trials, adverse events of hypoglycemia were reported based on clinical judgment of the 15mg and did not require confirmation with fingerstick glucose testing.

What Are the Side Effects of Actos (Pioglitazone)?

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