80mg fluoxetine daily

If you think that you are experiencing a side effect from your medication, talk with your physician. My doctor increased my Prozac from 40 mg daily to 60 mg. Could the higher prozac dose be causing this? For some people, this effect does go away after a period of time when the drug levels become more level in the body.

Would taking Prozac cause me to have a delay in speaking or studder? According to the prescribing information available for Prozac fluoxetine , change in speech and stuttering are reported as possible side effects. For more information on depression: Does Prozac have any long-term health risks? Prozac fluoxetine is a selective serotonin reuptake inhibitor SSRI antidepressant used to treat major depressive disorder, eating disorders, obsessive-compulsive disorder, premenstrual dysphoric disorder, and panic disorder.

Many patients have been on Prozac for many years without adverse effects. Prozac is considered safe to use long term if needed. Warnings from the prescribing information for Prozac include the following. Prozac like all antidepressants can increase the risk of suicidal thinking and behavior in children and young adults, especially when the medication is first started.

Prozac may worsen psychosis in some patients or cause mania in patients with bipolar disorder. Prozac should be used with caution in patients with seizure disorders, liver or kidney disease, and history of heart disease.

Prozac may cause weight changes, sleep changes, and sexual dysfunction. Patients who have been on Prozac long term and wish to stop the medication will need to taper the dose down to prevent withdrawal symptoms. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. My daughter takes Prozac and she doesn't swallow the pills, so I open up the capsule and put it in pudding. Is that making any difference in the medication?

I could find nothing saying that Prozac causes any problems being used the way you described. I would recommend she swallow the pudding and not chew it. I don't know if this would be any easier for her or not but it is always an option. I'm taking Prozac and wonder if it's causing the skin discoloration I'm getting on my back? There is no indication that Prozac fluoxetine would cause this symptom.

If this condition persists, please see your physician or dermatologist. Can being on Prozac make you loss your sexual drive? Unfortunately, a common side effect of Prozac the generic is fluoxetine and other SSRIs selective seratonin reuptake inhibitors like it is a decrease in sex drive.

Depression can also decrease sex drive. To help with this, it's recommended that you take your regular dose after the time you would normally expect to have sex. This gives more time until the next time you want to have sex, and the drug should cause less of the side effect by then.

Your doctor could also prescribe a medication to help with a low sex drive. And you could talk to your doctor about taking a "drug holiday," scheduling a day or two off of the drug each week. If none of these options work, you may need to try a different antidepressant. Always discuss the options with your doctor first to see what would be the best choice for you. What are the possible Prozac withdrawal symptoms? There are possible Prozac fluoxetine withdrawal symptoms which may be associated with abrupt discontinuation of the medication.

According to the prescribing information for Prozac, during marketing of Prozac, serotonin norepinephrine reuptake inhibitors SNRIs and selective serotonin reuptake inhibitors SSRIs , there were spontaneous reports of withdrawal symptoms which occurred upon discontinuation of these medications, particularly when discontinuation was abrupt.

Possible Prozac withdrawal symptoms may include dysphoric mood, irritability, agitation, dizziness, sensory disturbances, such electric shock sensations, anxiety, confusion, headache, lethargy, excessive emotional reactions and frequent mood changes, insomnia and hypomania.

Marketing research indicated that most of these reactions were typically self-limiting and did not require treatment. However, there were reports of serious symptoms associated with discontinuation. Patients are advised against abrupt discontinuation of Prozac.

Patients are also advised to take Prozac exactly as prescribed and should not alter the dosing regimen or discontinue treatment with Prozac without consulting their health care provider. Patients should be appropriately monitored, by their health care provider, for these symptoms during the discontinuation period.

To avoid the possible Prozac withdrawal symptoms, it is recommended for patients to gradually reduce the dosage of Prozac rather than abruptly discontinue treatment. An appropriate tapering period which implements a gradual dosage reduction should be under the supervision of a health care provider.

As a result of the long elimination half-lives of Prozac and its active metabolite, norfluoxetine, concentrations in the blood gradually decrease upon appropriate discontinuation of treatment which minimizes the risk for developing the possible Prozac withdrawal symptoms. Typically, even when treatment has been discontinued, active drug substances remain in the body for weeks, depending on patient specific characteristics, as well as previous dosing regimen and length of treatment.

What is the recommended Prozac dosage? The recommended Prozac fluoxetine dosage depends upon the indication for treatment. Prozac is a selective serotonin reuptake inhibitor SSRI antidepressant indicated for major depressive disorder, obsessive-compulsive disorder, bulimia and panic disorder, with or without agoraphobia. For the treatment of major depressive disorder in adults, the initial Prozac dosage is 20 mg per day administered in the morning. The usual recommended Prozac dosages range from 20 to 80 mg per day.

According to clinical studies, 20 mg per day is typically an adequate Prozac dosage to achieve a satisfactory therapeutic response in most cases of major depressive disorder. Dosages greater than 20 mg per day may be administered once daily in the morning or twice daily morning and noon if necessary. Maximum daily doses should not exceed 80 mg per day.

Prozac has also been proven effective for once weekly administration. For the treatment of major depressive disorder in the pediatric population, 8 years of age and older, the usual recommended Prozac dosage is 10 to 20 mg per day. Treatment with Prozac for major depressive disorder may require four weeks or longer before the full pharmacologic effect is observed. For the treatment of obsessive-compulsive disorder in adults, the initial Prozac dosage is 20 mg per day administered in the morning.

The usual recommended Prozac dosages range from 20 to 60 mg per day. However, 80 mg per day dosages have been well tolerated in clinical studies. The maximum daily dose is 80 mg. For the treatment of obsessive-compulsive disorder in adolescents and higher weight children, 7 years of age and older, the usual recommended Prozac dosage is 20 to 60 mg per day with an initial dosage of 10 mg per day.

For lower weight children, 20 to 30 mg per day is recommended. For the treatment of bulimia nervosa in adults, the usual recommended Prozac dosage is 60 mg per day administered in the morning.

In some patients, dose titration over several days may be advisable. For the treatment of panic disorder in adults, the initial Prozac dosage is 10 mg per day. According to the prescribing information, the dosage should be increased to 20 mg daily after one week of treatment.

The usual recommended Prozac dosage is 20 mg per day administered in the morning. During clinical trials, patients were administered dosages ranging from 10 to 60 mg. A dosage of 20 mg was most frequently administered to patients during clinical trials. For all indications of Prozac, it may require four weeks of treatment or longer before patients experience improvements in symptoms.

It is essential for patients to continue with treatment exactly as directed to achieve desired therapeutic outcomes. What is the difference between generic and brand Prozac? In most patients, there is no significant difference between generic and brand Prozac fluoxetine. There is currently a generic equivalent available for Prozac, known as fluoxetine.

Food and Drug Administration FDA requires that generic medications be bioequivalent to the brand-name medication and, therefore, exert the same pharmacologic effects in the body. Generic medications are considered, by the FDA, to be therapeutically identical to the brand-name counterparts in dose, strength, route of administration, safety, efficacy and indication for use.

Generic medications will appear differently and may have different inactive ingredients, however, the labeling and directions for use remain the same. For most medications, generic equivalents are a lower-cost alternative to the more expensive brand-name medication, and the majority of patients observe no changes in therapeutic effect.

However, some patients may experience a change in therapeutic effect and, subsequently, must continue treatment with the brand-name medication. Generic Prozac, fluoxetine, is a selective serotonin reuptake inhibitor SSRI antidepressant which is approved for the treatment of major depressive disorder, obsessive-compulsive disorder OCD , panic disorder and bulimia nervosa.

Frequently reported side effects for generic Prozac are similar those observed in patients being treated with the brand-name medication and may include abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia, diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, decreased libido, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation and yawn.

The warnings and precautions associated with Prozac are also possible with the generic fluoxetine. According to the prescribing information for Prozac, warnings and precautions, possible with treatment, include clinical worsening of depression and suicide risk, serotonin syndrome or neuroleptic malignant syndrome-like reactions, allergic reactions and rash, activation of mania or hypomania, seizures, altered appetite and weight, abnormal bleeding, hyponatremia, possibility of anxiety and insomnia, potential for cognitive and motor impairment and long half-life affecting changes in dosage.

Fluoxetine, generic Prozac, should be administered exactly the same as the brand-name medication. Fluoxetine is typically taken once daily and administered in the morning.

Is Prozac for insomnia? Prozac fluoxetine is not indicated for insomnia treatment by the U. Prozac is approved by the FDA for the treatment of several other medical conditions including depression, obsessive-compulsive disorder, bulimia nervosa and panic disorder.

During clinical trials, one of the most commonly observed adverse reactions in patients being treated with Prozac, for any indication, was insomnia. Patients should be advised to take Prozac exactly as directed by their health care provider. If patients experience unpleasant or bothersome adverse reactions, such as insomnia, they are also advised not to change their dosing regimen or discontinue treatment without consulting with their health care provider.

Prozac fluoxetine is an antidepressant categorized as a selective serotonin reuptake inhibitor SSRI. Prozac is approved, by the U. Food and Drug Administration FDA for the acute and maintenance treatment of major depressive disorder in adult and pediatric patients aged 8 to 18 years, the acute and maintenance treatment of obsessive-compulsive disorder in adult and pediatric patients aged 7 to 17 years, the acute and maintenance treatment of bulimia nervosa in adult patients and the acute treatment of panic disorder, with or without agoraphobia in adult patients.

Prozac is typically administered in the morning and the recommended dosage depends on indication for use. Prozac is available in a capsule formulation in 10 mg, 20 mg and 40 mg strengths. Prozac is also available in a capsule formulation for weekly administration in 90 mg strength. At least five weeks should be allowed after discontinuation of Prozac treatment prior to initiation of treatment with an MAOI because of the long half-life of Prozac.

Prozac is also contraindicated in patients being treated with pimozide and thioridazine because of dangerous drug interactions. Do not use thioridazine within five weeks of discontinuing Prozac treatment. There are several warnings and precautions associated with Prozac treatment that patients should discuss in detail with their health care provider and understand fully prior to initiation of treatment. According to the prescribing information, the warnings and precautions, possible with Prozac treatment, include clinical worsening of depression and suicide risk, serotonin syndrome or neuroleptic malignant syndrome-like reactions, allergic reactions and rash, activation of mania or hypomania, seizures, altered appetite and weight, abnormal bleeding, hyponatremia, possibility of anxiety and insomnia, potential for cognitive and motor impairment and long half-life affecting changes in dosage.

Prozac is extensively metabolized broken down in the liver by the cytochrome P system and, therefore, has the potential to interact with several medications. It is essential for patients to inform their health care provider of all medications they are currently taking, including prescription medications, over the counter products and dietary or herbal supplements.

Treatment with Prozac, for all indications, may require four weeks of treatment or longer before patients experience improvements in symptoms. What are the benefits and risks of Prozac? There are several benefits and risks of Prozac fluoxetine.

For most patients, the benefits outweigh the risks of treatment with Prozac. However, there are still various risks a patient should be aware of prior to initiation of therapy.

The benefits of Prozac extend across many medical conditions. Prozac, a selective serotonin reuptake inhibitor SSRI antidepressant, is a proven effective treatment option and has demonstrated benefits in patients with major depressive disorder, obsessive-compulsive disorder, panic disorder and bulimia.

In addition, Prozac has proven benefits for major depressive disorder and obsessive-compulsive disorder in the pediatric population as well.

There are no drug treatments that are not without risk, including Prozac. One of the risks of Prozac treatment is the commonly occurring side effects. The most commonly reported side effects in patients treated with Prozac include abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia, diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, decreased libido, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation and yawn.

Other risks of Prozac include several warnings and precautions which may occur with treatment. There is a risk of clinical worsening of depression symptoms and risk of suicide in both the adult and pediatric population. Clinical trials revealed that antidepressant drugs increase the risk of suicidality in children, adolescents and young adults ages 18 to 24 with major depressive disorder and other psychiatric disorders.

According to the prescribing information, all patients being treated with antidepressants, including Prozac, for any indication should be closely monitored and observed for clinical worsening, suicidality and unusual changes in behavior, especially during the first few months of therapy or during times of dosage adjustments. Patients should be monitored for the following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathesia, hypomania and mania.

These symptoms have been reported in adults and the pediatric population being treated with antidepressants for major depressive disorder, in addition to other psychiatric and nonpsychiatric indications. It is important to advise patients taking Prozac to be aware of the risk for serotonin syndrome or neuroleptic malignant syndrome NMS -like reactions that may occur with SSRIs alone or with the concomitant use of Prozac and other serotonergic medications, such as the triptans medications used to treat migraine headaches , tramadol, serotonin-norepinephrine reuptake inhibitors SNRIs , such as Cymbalta duloxetine , Effexor venlafaxine or Pristiq desvenlafaxine , or other SSRIs.

Symptoms of serotonin syndrome or NMS-like reactions include agitation, confusion, increased heart rate and blood pressure, sweating, headache, diarrhea, loss of muscle coordination, and possibly fever and seizures. Seek immediate medical attention if you experience any of these signs and symptoms. Prozac may cause an increased risk for bleeding. Patients taking Prozac should discuss the concomitant use of Prozac with non-steroidal anti-inflammatory drugs NSAIDs , including ibuprofen and naproxen, aspirin, warfarin or other medications that affect coagulation with their physician to avoid an increased risk for bleeding.

Before taking any of these medications, it is important to consult with your physician and call your physician immediately if you experience any bleeding or bruising. Hyponatremia low levels of sodium in the blood has been reported as a result of Prozac treatment.

It is important to be aware of the signs and symptoms associated with hyponatremia so you can recognize them if they occur. Signs and symptoms include headache, difficulty concentrating, memory impairment, confusion, weakness, unsteadiness, hallucination, passing out, seizure, coma, respiratory arrest and death.

Patients should discuss the benefits and risks of Prozac with their health care provider prior to initiation of treatment. What is the difference between Cymbalta versus Prozac? There are a number of differences between Cymbalta duloxetine versus Prozac fluoxetine.

The main differences between Cymbalta versus Prozac include mechanism of action, the way in which the drug works in the body, and indications for use approved by the U.

Cymbalta is a potent inhibitor of both serotonin and norepinephrine reuptake in the central nervous system, while Prozac is a much more potent inhibitor of serotonin reuptake than norepinephrine. The only common indication between Cymbalta and Prozac is major depressive disorder. Cymbalta belongs to a class of antidepressants known as serotonin norepinephrine reuptake inhibitors SNRI and is indicated for the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain.

Prozac belongs to a different class of antidepressants known as selective serotonin reuptake inhibitors SSRI and is indicated for the treatment of major depressive disorder, obsessive-compulsive disorder, panic disorder and bulimia nervosa. Another difference between Cymbalta versus Prozac is approved use in the pediatric population.

While Prozac is currently approved, by the FDA, for the treatment of major depressive disorder and obsessive-compulsive disorder in the pediatric population, both in children and adolescents, the safety and effectiveness of Cymbalta in the pediatric population has not been established. Another difference between Cymbalta versus Prozac is there is currently no generic equivalent available for Cymbalta, while Prozac is available in a generic form, known as fluoxetine.

Cymbalta and Prozac have similar adverse reactions and warnings and precautions associated with treatment. However, Cymbalta has been associated with an increased risk of mydriasis prolonged dilation of the pupils of the eye and should be used cautiously in patients with controlled narrow-angle glaucoma.

Patients should be advised to discuss with their health care provider if they have a past medical history of glaucoma prior to initiation of treatment with Cymbalta. Another difference between Cymbalta versus Prozac, with regard to warnings and precautions, Cymbalta treatment was observed to worsen glycemic control in some patients with diabetes during clinical trials.

How do I take Prozac for depression? To take Prozac fluoxetine for depression, patients should be advised that treatment may require four weeks or longer before the full therapeutic effect of Prozac is observed. It is essential for patients to take Prozac for depression exactly as prescribed by a health care provider and not to adjust the dosing regimen or discontinue treatment with Prozac without the supervision of their doctor.

Prozac is indicated for the treatment of depression in adult and pediatric patients, aged 8 to 18 years. To take Prozac for depression, the initial adult dose is 20 mg per day administered in the morning. The usual dosage of Prozac for depression ranges from 20 to 80 mg daily. During clinical trials for depression, 20 mg daily was an adequate dosage, in most patients, to achieve a desired therapeutic outcome.

Research suggests that dosages higher than 20 mg per day may be administered once daily in the morning or may be administered twice daily when necessary, in the morning and at noon. To take Prozac for depression, the maximum daily dose is 80 mg. Prozac for weekly administration is also effective for treating depression in adults. To take Prozac for depression in children and adolescents, age 8 and older, the usual dose of Prozac is 10 to 20 mg daily.

For both adult and pediatric patients, an increase in dosage of Prozac may be considered after several weeks of treatment if a less than satisfactory clinical improvement is observed.

It is essential that patients are periodically monitored and reassessed to determine if further treatment is required. When taking Prozac for depression, doses are typically administered in the morning unless otherwise instructed. Patients taking Prozac for depression should be informed regarding the most commonly observed adverse reactions. Prior to beginning treatment with Prozac for depression, it is essential to inform your physician of any other medications you are currently taking, including prescription medications, over the counter products and dietary or herbal supplements to avoid potentially dangerous interactions.

How can I lose weight after Prozac? In placebo-controlled clinical trials for major depressive disorder, obsessive-compulsive disorder and bulimia nervosa, altered appetite and weight after beginning Prozac treatment was reported. Patients did not report weight gain or difficulty losing weight during clinical studies or postmarketing experience with Prozac. Prozac is a potent inhibitor of neuronal serotonin reuptake in the central nervous system and therefore categorized as a selective serotonin reuptake inhibitor SSRI.

Prozac is used for the treatment of bulimia, panic disorder, obsessive-compulsive disorder and major depressive disorder. The tools with which to lose weight after Prozac are the same as those for any other individual attempting to lose weight. In general, irrespective of drug therapy, the safest and most effective method for long-term weight loss is proper diet and exercise.

Eating a healthy, well-balanced diet full of fruits, vegetables and whole grains while limiting sugar, processed foods and alcohol typically people lose weight.

According to the National Heart Lung and Blood Institute NHLBI , a part of the National Institutes of Health NIH , to lose weight it is essential for individuals to make lifestyle changes which focus on reducing calories from food and drink, a healthy eating plan and proper portion control. Furthermore, the NHLBI outlines a healthy eating plan to control portion sizes and include fruits, vegetables, whole grains and fat-free or low-fat dairy products.

A healthy eating plan should also include lean meats, poultry, fish, beans, eggs and nuts and be low in saturated fat, trans fat, cholesterol, sodium and added sugars.

To safely and effectively lose weight, in general and after Prozac, individuals need to expend more calories than they take in. Essentially, individuals need to reduce their daily caloric intake from food and beverages and increase calories burned through physical exercise. An appropriate diet and exercise regimen should initially be under the guidance of a physician. How can I treat bipolar disorder with Prozac? To treat bipolar disorder with Prozac fluoxetine , another medication must be prescribed in combination.

Prozac is not currently approved as monotherapy for the treatment of depressive episodes associated with bipolar disorder. Symbyax is approved by the U. Food and Drug Administration FDA for the acute treatment of depressive episodes associated with bipolar disorder in adults. To treat bipolar disorder with Prozac in combination with olanzapine most physicians will prescribe combination Symbyax.

The efficacy of Symbyax for the acute treatment of depressive episodes associated with bipolar disorder was established in controlled studies. Symbyax should be administered once daily in the evening. While both Prozac and olanzapine individually can be administered without regard to meals, the effect of food on Symbyax specifically has not been evaluated.

According to the prescribing information for Symbyax, dosage changes should be assessed according to efficacy and patient tolerability. The ideal duration of treatment with Symbyax is unknown and patients should be periodically reassessed by a health care provider to determine if continued treatment is necessary. Patients should be advised to avoid alcohol while being treated with Symbyax. To treat bipolar disorder with Symbyax, it is important for patients to take this medication exactly as prescribed even after mood symptoms improve.

Patients should also be advised not to adjust their dosing regimen or discontinue treatment with Symbyax without the supervision of their health care provider. What condition is Prozac used for? Is it used in weight reduction? What are the side effects? Prozac fluoxetine is a medication that is used to treat depression, panic disorder, obsessive compulsive disorder OCD , depression associated with bipolar disorder, as well as other conditions.

It is in the class of medications called selective serotonin reuptake inhibitors SSRIs and works by bringing a balance to serotonin in the brain that may be the cause of symptoms. The prescribing information on Prozac lists the following as the most common side effects associated with the medication: Prozac is not approved by the U. Weight loss appears to be a side effect that occurs in up to 2 percent of patients taking Prozac.

It is not entirely clear why this medication causes weight loss, although it is generally a small amount. It may be due to the side effects of loss of appetite, diarrhea and nausea that may contribute to the weight loss.

My doctor recently told me to try to increase my 20 mg of Prozac to 40 mg. I tried it, and it made me exhausted during the day and woke me up in the middle of the night. Prozac fluoextine belongs to the class of drugs called selective serotonin reuptake inhibitors SSRIs. Common side effects of Prozac include dry mouth, drowsiness, nausea, and weight changes. Other side effects of Prozac include gas, sleep problems, and loss of appetite.

Prozac may also cause insomnia. It is important to consult with your health care provider regarding the symptoms that you are experiencing. Prozac may be taken with or without food and at anytime of the day. Is it possible to become tolerant to the effects of Prozac? The most common side effects with Prozac include abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia weakness , diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, libido decreased, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation, and yawn.

With antidepressants, it is possible to have a worsening of symptoms. Contact your doctor right away if you have any new or worsening symptoms of depression. You should also call your doctor if you are experiencing mood or behavior changes, anxiety or panic attacks, sleep problems, impulsivity, irritability, agitation, hostility, aggression, restlessness, hyperactivity, or if you are having thoughts of suicide or hurting yourself. Worsening of symptoms may be more likely to occur during the first few months of therapy and during dosage changes either increasing or decreasing doses.

Do not change the amount of medication you take without talking to your doctor first. Does Prozac cause problems with eyesight? Food and Drug Administration FDA , for the treatment of major depressive disorder, depressive episodes associated with bipolar disorder, obsessive-compulsive disorder OCD , bulimia nervosa, and panic disorder. Some of the most common side effects associated with Prozac include insomnia, headache, weakness, nausea, runny nose, drowsiness, diarrhea, and anorexia.

According to the prescribing information for Prozac, abnormal vision and visual field defects were reported as potential side effects occurring in 4 percent and less than 1 percent respectively of patients taking Prozac during clinical trials. Prozac may be taken with or without food.

If Prozac causes an upset stomach, it may be helpful to take it with food. Prozac may take several weeks to work after treatment is first started. Prozac will only work if taken daily and exactly as prescribed. Prozac should not be taken on an as needed basis.

If Prozac needs to be discontinued, the dose should be slowly tapered down, under the supervision of a health care provider, rather than suddenly stopped to prevent withdrawal symptoms.

Patients who are taking Prozac should avoid alcohol use. Do not stop taking your medication without first taking to your doctor. What are the side effects of a Prozac overdose? Prozac fluoxetine is prescription medication commonly used to treat depression, generalized anxiety disorder, obsessive-compulsive disorder, and panic disorder. Prozac should be taken regularly, at the same time every day, with or without food.

Prozac can be taken at any time during the day, but should be taken around the same time every day. Women who discontinued antidepressant medication during pregnancy showed a significant increase in relapse of their major depression compared to those women who remained on antidepressant medication throughout pregnancy.

When treating a pregnant woman with PROZAC, the physician should carefully consider both the potential risks of taking an SSRI, along with the established benefits of treating depression with an antidepressant.

Animal Data In embryo-fetal development studies in rats and rabbits, there was no evidence of teratogenicity following administration of fluoxetine at doses up to However, because fluoxetine crosses the placenta and because of the possibility that fluoxetine may have adverse effects on the newborn, fluoxetine should be used during labor and delivery only if the potential benefit justifies the potential risk to the fetus.

In one breast-milk sample, the concentration of fluoxetine plus norfluoxetine was No adverse effects on the infant were reported. In another case, an infant nursed by a mother on PROZAC developed crying, sleep disturbance, vomiting, and watery stools. Manic reaction, including mania and hypomania, was reported in 6 1 mania, 5 hypomania out of 2.

As with other SSRIs, decreased weight gain has been observed in association with the use of fluoxetine in children and adolescent patients. After 19 weeks of treatment in a clinical trial, pediatric subjects treated with fluoxetine gained an average of 1. In addition, fluoxetine treatment was associated with a decrease in alkaline phosphatase levels. The safety of fluoxetine treatment for pediatric patients has not been systematically assessed for chronic treatment longer than several months in duration.

In particular, there are no studies that directly evaluate the longer-term effects of fluoxetine on the growth, development and maturation of children and adolescent patients. Therefore, height and weight should be monitored periodically in pediatric patients receiving fluoxetine. Anyone considering the use of PROZAC in a child or adolescent must balance the potential risks with the clinical need.

Animal Data Significant toxicity on muscle tissue, neurobehavior, reproductive organs, and bone development has been observed following exposure of juvenile rats to fluoxetine from weaning through maturity.

When animals were evaluated after a drug-free period up to 11 weeks after cessation of dosing , fluoxetine was associated with neurobehavioral abnormalities decreased reactivity at AUC as low as approximately 0. In addition, the testicular and epididymal microscopic lesions and decreased sperm concentrations found in high dose group were also observed, indicating that the drug effects on reproductive organs are irreversible.

The reversibility of fluoxetine-induced muscle damage was not assessed. These fluoxetine toxicities in juvenile rats have not been observed in adult animals. Rat exposures to the major metabolite, norfluoxetine, are approximately 0. A specific effect on bone development was reported in juvenile mice administered fluoxetine by the intraperitoneal route to 4 week old mice for 4 weeks at doses 0.

There was a decrease in bone mineralization and density at both doses, but the overall growth body weight gain or femur length was not affected. Safety and effectiveness of PROZAC and olanzapine in combination in patients less than 10 years of age have not been established.

The efficacy in geriatric patients has been established [see Clinical Studies ]. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Hepatic Impairment In subjects with cirrhosis of the liver, the clearances of fluoxetine and its active metabolite, norfluoxetine, were decreased, thus increasing the elimination half-lives of these substances. A lower or less frequent dose of fluoxetine should be used in patients with cirrhosis. Of the cases of overdose involving fluoxetine hydrochloride, alone or with other drugs, reported from this population, there were deaths.

Among adult patients who overdosed on fluoxetine hydrochloride alone, 34 resulted in a fatal outcome, completely recovered, and 15 patients experienced sequelae after overdosage, including abnormal accommodation , abnormal gait , confusion , unresponsiveness, nervousness, pulmonary dysfunction, vertigo , tremor , elevated blood pressure, impotence , movement disorder, and hypomania.

The remaining patients had an unknown outcome. The most common signs and symptoms associated with non-fatal overdosage were seizures, somnolence , nausea, tachycardia , and vomiting. The largest known ingestion of fluoxetine hydrochloride in adult patients was 8 grams in a patient who took fluoxetine alone and who subsequently recovered.

However, in an adult patient who took fluoxetine alone, an ingestion as low as mg has been associated with lethal outcome, but causality has not been established.

Among pediatric patients ages 3 months to 17 years , there were cases of overdose involving fluoxetine alone or in combination with other drugs. Six patients died, patients completely recovered, 1 patient experienced renal failure, and 22 patients had an unknown outcome. He had been receiving mg of fluoxetine daily for 6 months in addition to clonidine, methylphenidate, and promethazine.

Mixed-drug ingestion or other methods of suicide complicated all 6 overdoses in children that resulted in fatalities. The largest ingestion in pediatric patients was 3 grams which was nonlethal.

Other important adverse reactions reported with fluoxetine overdose single or multiple drugs include coma, delirium , ECG abnormalities such as nodal rhythm, QT interval prolongation and ventricular arrhythmias , including Torsades de Pointes-type arrhythmias , hypotension , mania , neuroleptic malignant syndrome-like reactions, pyrexia, stupor, and syncope. Animal Experience Studies in animals do not provide precise or necessarily valid information about the treatment of human overdose. However, animal experiments can provide useful insights into possible treatment strategies.

Acute high oral doses produced hyperirritability and convulsions in several animal species. Tachycardia and an increase in blood pressure were observed. Consequently, the value of the ECG in predicting cardiac toxicity is unknown. Treatment should consist of those general measures employed in the management of overdosage with any drug. Consider the possibility of multi-drug overdose. Ensure an adequate airway, oxygenation , and ventilation. Monitor cardiac rhythm and vital signs.

Use general supportive and symptomatic measures. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at What should I avoid while taking fluoxetine? Drinking alcohol can increase certain side effects of fluoxetine. Fluoxetine and alcohol in more detail Ask your doctor before taking a nonsteroidal anti-inflammatory drug NSAID for pain, arthritis, fever, or swelling.

This includes aspirin, ibuprofen Advil, Motrin , naproxen Aleve , celecoxib Celebrex , diclofenac, indomethacin, meloxicam, and others. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Fluoxetine side effects Get emergency medical help if you have signs of an allergic reaction to fluoxetine: Report any new or worsening symptoms to your doctor, such as: Call your doctor at once if you have:

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