Usual dose in adults: For the treatment of anaemia low red blood cells: Prevention of spina bifida: One tablet a day, starting before conception and continuing for the first three months of pregnancy If you take more Folic Acid Tablets than you should: If you or anybody else, including a child , takes more Folic Acid Tablets than you should, it is unlikely that this medicine will cause any harm.

If you are at all concerned contact your doctor. Always take the carton and this leaflet with you. If you forget to take your Folic Acid Tablets: If you forget to take a dose, take another as soon as you remember.

If it almost time for your next dose, then do not take the missed dose at all. NEVER take a double dose to make up for the one missed. Tell your doctor if you notice any of the following side effects, they get worse or you notice any not listed: Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.

You can also report side effects directly via the yellow card scheme at www. By reporting side effects you can help provide more information on the safety of this medicine.

Do not use Folic Acid Tablets after the expiry date which is stated on the box. If your medicine is out of date, take it to your pharmacist who will get rid of it safely. Mortality and cardiovascular events in patients treated with homocysteine-liowering B vitamins after coronary angiography. Homocysteine lowering interventions for preventing cardiovascular events. Homocysteine-lowering interventions for preventing cardiovascular events.

Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Folate nutrition and growth in infancy. Folate therapy in epilepsy. Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. Geriatr Cogn Disord ;13 4: Treatment of hyperhomocysteinemia with folic acid: Lessons learned from randomized clinical trials of micronutrient supplementation for cancer prevention.

The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Am J Clin Nutr ;84 1: Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: Homocysteine, B-vitamins and CVD.

High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: Effect of homocysteine interventions on the risk of cardiocerebrovascular events: Int J Clin Pract.

Can folic acid protect against congenital heart defects in Down syndrome? Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene.

Am J Clin Nutr ;80 3: A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr ;84 5: Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults. Am J Clin Nutr ;79 3: Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels.

Am J Cardiol ; 4: Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol ;99 4: Homocysteine, vitamin B, and folic acid and the risk of cognitive decline in old age: Am J Clin Nutr ;82 4: The effect of nutritional supplementation on calorie and protein intake of pregnant women.

Nutr Rep Intl ; Nutritional determinants of cognitive aging and dementia. Dietary folate and vitamins B and B-6 not associated with incident Alzheimer's disease. Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India.

Indian J Med Res ; Role of folic acid in atherosclerosis after kidney transplant: Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.

Nutritional profile of newborns of adolescent mothers supplemented with iron, in different concentrations, zinc and pholic acid. Brazilian Journal of Nutrition ;15 2: The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg ;80 Cardiovascular consequences of ovarian disruption: Folic acid-preventable spina bifida: The scientific basis for eliminating folic acid-preventable spina bifida: Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Am J Clin Nutr ;91 2: Effect of the Bvitamins on cognitive function in elderly people with mild cognitive dysfunction. Clin Chem Lab Med ; Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Am J Clin Nutr ;92 6: Effect of folic acid and betaine supplementation on flow-mediated dilation: Clin Trials ;1 2: The effect of folic acid and iron in the prevention of nutritional anaemias in pregnancy in Nigeria.

Br J Nutr ;24 3: Reduction of the incidence of metachronous adenomas of the large bowel by means of antioxidants. Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: Folates and S-adenosylmethionine for major depressive disorder. Homocysteine lowering with folic acid supplements in children: Int J Food Sci Nutr ;61 1: Folate supplementation and adenomatous colonic polyps. Colon Rectum ;37 Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes.

Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Folic acid improves endothelial function in children and adolescents with type 1 diabetes. J Pediatr ; 4: Folic acid does not improve endothelial function in obese children and adolescents.

Diabetes Care ;30 8: Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Daily oral iron supplementation during pregnancy. Nutrition and vascular dementia. Health Aging ;16 4: Incidence of open neural tube defects in Nova Scotia after folic acid fortification. Vitamins and progression of atherosclerosis in hyper-homocyst e inaemia. Randomised trial of prophylactic daily aspirin in British male doctors.

Ponz de, Leon M. Chemoprevention of colorectal tumors: Scand J Gastroenterol Suppl ; Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. Homocysteine-lowering therapy and early progression of transplant vasculopathy: Long-term effect of folic acid therapy in heart transplant recipients: The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: Prevention of neural tube defects: Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: Clin J Am Soc Nephrol.

Effect of folic acid supplementation on the progression of carotid intima-media thickness: Effects of folic acid on fit-frequency and behaviour in epileptics on anticonvulsants. Do multiple micronutrient interventions improve child health, growth, and development? Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B, and cognitive function.

Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification.

Am J Clin Nutr ;80 4: Effects of multivitamin and folic acid supplementation in malnourished children. Conversion of mild cognitive impairment to dementia: Homocysteine and folate as risk factors for dementia and Alzheimer disease.

Am J Clin Nutr ;82 3: Folic acid and homocyst e ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: Homocysteine-lowering therapy and risk for venous thromboembolism: Association between folic acid food fortification and congenital orofacial clefts. J Pediatr ; 6: Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: Declining rate of folate insufficiency among adults following increased folic acid food fortification in Canada.

J Public Health ;93 4: Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients.

Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid. Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation. Effect of folic acid treatment on premature infants. Dietary folate consumption and breast cancer risk.

Folic acid supplement and intrauterine growth. Efficacy of different strategies to treat anemia in children: Folate levels and cancer morbidity and mortality: Micronutrient intake and breast cancer characteristics among postmenopausal women. Systematic review of pharmacological treatments in fragile X syndrome.

Folic acid for fragile X syndrome. A randomized controlled trial of prenatal nutritional supplementation in New York City. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Folic acid supplementation during treatment of psoriasis with methotrexate: B-vitamin supplementation lowers homocysteine levels in heart disease.

Response to oral administration of pteroylmonoglutamic acid or pteroylpolyglutamate in newborn infants of low birth weight. Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. Folate intake and colorectal cancer risk: Int J Cancer ; 5: Meta analysis suggests that folic acid supplementation does not reduce risk of stroke, but there may be some benefit when given in combination with vitamins B6 and B12 and in primary prevention.

Based Med ;15 6: Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa.

Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease.

Eur J Clin Invest ;36 5: Z Gastroenterol ;42 9: The responsiveness of plasma homocysteine to small increases in dietary folic acid: Homocysteine, B-vitamin supplementation, and stroke prevention: Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. High-folate diets and breast cancer survival in a prospective cohort study.

Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.

J Med ; 7: Folate and breast cancer: Folate and amine metabolites in senile dementia: Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects.

Dietary folate intake and lung cancer risk in former smokers: Global improvement of vascular function and redox state with low-dose folic acid: Multiple micronutrient supplementation during pregnancy in developing-country settings: Food Nutr Bull ;30 4 Suppl: MTHFR polymorphisms, dietary folate intake, and breast cancer risk: Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women.

Magnesium supplementation during pregnancy: A double-blind trial of zinc supplementation in pregnancy. Eur J Clin Nutr ;45 3: Risk factors for gout and prevention: Can vitamins prevent neural tube defects? Med Assoc J ; 4: Further experience of vitamin supplementation for prevention of neural tube defect recurrences.

Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging. Homocysteine, vitamins, and vascular disease prevention: Am J Clin Nutr ;87 4: The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients.

Folic acid supplementation in dementia: The effects of supplemental oral iron administration to pregnant women. Magnesium supplementation in pregnancy. Measurement of carotid plaque and effect of vitamin therapy for total homocysteine.

Lab Med ;41 No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia. J Med ;62 7: A prophylactic supplementation of iron and folate in pregnancy.

Folic acid supplementation in low birth weight infants. Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort. Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am J Clin Nutr ;65 1: Use of folic acid supplements, particularly by low-income and young women: Public Health Nutr ;11 8: Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol ;42 Suppl 3 Pt 2: Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: One-carbon metabolism-related gene polymorphisms and risk of breast cancer.

ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst e inemia: A systematic review of natural health product treatment for vitiligo.

Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. Eur J Nutr ;43 5: Folate for depressive disorders: J Psychopharmacol ;18 2: Maternal folate status, birthweight and gestational age. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls.

Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. The nutrition of expectant and nursing mothers in relation to maternal and infant mortality and morbidity.

Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis. Periconceptional multivitamin folic acid use, dietary folate, total folate and risk of neural tube defects in South Carolina. Effects of extended systemic and topical folate supplementation on gingivitis of pregnancy. Intake of fruits, vegetables, folic acid and related nutrients and risk of breast cancer in postmenopausal women.

Public Health Nutr ;1 3: A dose-finding trial of the effect of long-term folic acid intervention: Am J Clin Nutr ;93 1: Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering. Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark.

Policy statement on folic acid and neural tube defects. Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Folic acid fortification of the food supply.

Potential benefits and risks for the elderly population. Hyperhomocysteinemia and the response to vitamin supplementation. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.

Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: Hyperhomocysteinemia and Alzheimer's disease: Adjuvant treatment of colon cancer: Diet and nutrient factors in colorectal cancer risk.

Primary prevention of neural tube defects with folic acid supplementation: A prospective study of plasma homocyst e ine and risk of ischemic stroke. Recommendations and expert opinion on the adjuvant treatment of colon cancer in Spain.

Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations. Calcium supplementation reduces blood pressure during pregnancy: Is Hyperhomocyst e inemia a humoral predictor of coronary heart disease?

Curr Pharm Des ;11 Effect of folic acid, with or without other B vitamins, on cognitive decline: Am J Med ; 6: Serum homocysteine and dementia: Homocysteine and cardiovascular disease: Reconciling the evidence on serum homocysteine and ischaemic heart disease: Blood folic acid and vitamin B12 in relation to neural tube defects.

Br J Obstet Gynaecol ; 4: Vitamin B 12 and folate in relation to the development of Alzheimer's disease. Folate and risk of coronary heart disease: Low maternal vitamin B 12 is a risk factor for neural tube defects: Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: J Rheumatol ;20 6: Homocysteine as a risk factor for cardiovascular and related disease: Effect of supplemental folic acid in pregnancy on childhood asthma: The natural history of vascular disease in homocystinuria and the effects of treatment.

Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr ;82 1: Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States.

Folic acid supplementation for the prevention of neural tube defects: Preventive Services Task Force. Intern Med ; 9: Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects. Clin Sci Lond ; 4: The effects of oral vitamin supplementation on cardiovascular risk factors. Roc Nutr Soc ; Interventions for preventing oral mucositis for patients with cancer receiving treatment.

Premature infants require additional folate and vitamin B to reduce the severity of the anemia of prematurity. Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. Role of homocysteine in end-stage renal disease. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr ;90 6: Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: Effect of routine iron supplementation with or without folic acid on anemia during pregnancy.

Efficacy of folic acid supplementation in cardiovascular disease prevention: Essential fatty acids preparation SR-3 improves Alzheimer's patients quality of life.

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. Patterns of treatment with chemotherapy and monoclonal antibodies for metastatic colorectal cancer in Western Europe.

Association between B-group vitamins and venous thrombosis: Effect of folic acid supplementation on cardiovascular outcomes: The interventional effect of folic acid on the development of gastric and other gastrointestinal cancers - Clinical trial and follow- up for seven years. Chinese Journal of Gastroenterology ;7: The effect of folic acid on the development of stomach and other gastrointestinal cancers.

Chin Med J ; Methyl-group dietary intake and risk of breast cancer among African-American women: Cancer Causes Control ;14 9: Meta-analysis of the relationship between homocysteine, vitamin B 1 2 , folate, and multiple sclerosis. Homocyst e ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease.

Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: J Am Coll Cardiol ;47 6: Folate administration reduces circulating homocysteine levels in NIDDM patients on long-term metformin treatment. J Int Med ; Prediction of treatment response in geriatric depression from baseline folate level: J Clin Psychopharmacol ; Interrelationship of rheumatoid arthritis, folic acid and aspirin.

Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Basic Principles and Practice. Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects.

J Assist Reprod Genet. Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Fish, meat, and risk of dementia: Calcium supplements for the prevention of colorectal adenomas.

Calcium Polyp Prev Study Group. N Engl J Med ; Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. J Natl Cancer Inst ; Megaloblastic anemia due to folic acid deficiency after oral contraceptives. Dietary intake of folate and risk of stroke in US men and women: Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients.

Arterioscler Thromb Vasc Biol ; Leucovorin calcium [package insert]. Effects of a biguanide metformin on vitamin B12 and folic acid absorption and intestinal enzyme activities. Scand J Gastroenterol ;6: Before and after folic acid administration. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc ; Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Enlg J Med ; Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: Preventive health care, update: Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients.

Bostom AG, Garber C. Endpoints for homocysteine-lowering trials. Treatment of hyperhomocysteinemia in renal transplant recipients. A randomized, placebo-controlled trial.

Ann Intern Med ; Ann Int Med ; Controlled comparison of LMethyltetrahydrofolate versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients.

Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients. Thiamine and folate treatment of chronic epileptic patients: Neurologic disorders responsive to folic acid therapy. Can Med Assoc J ; Relapsing neuropathy, cerebral atrophy and folate deficiency. The clinical potential of ademetionine S-adenosylmethionine in neurological disorders.

Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry ; A quantitative assessment of plasma homocysteine as a risk factor for vascular disease.

Probable benefits of increasing folic acid intakes. Folic acid-an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest ; Effects of folic acid and combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. N5-formyltetrahydroFolic Acid is leucovorin. TetrahydroFolic Acid derivatives are distributed to all body tissues but are stored primarily in the liver.

After a single oral dose of mcg of Folic Acid in a limited number of normal adults, only a trace amount of the drug appeared in the urine. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Small amounts of orally administered Folic Acid have also been recovered in the feces. Folic Acid is also excreted in the milk of lactating mothers. Indications and Usage for Folic Acid Folic Acid is effective in the treatment of megaloblastic anemias due to a deficiency of Folic Acid as may be seen in tropical or nontropical sprue and in anemias of nutritional origin, pregnancy, infancy, or childhood.

Contraindications Folic Acid is contraindicated in patients who have shown previous intolerance to the drug. Warnings Administration of Folic Acid alone is improper therapy for pernicious anemia and other megaloblastic anemias in which vitamin B12 is deficient. Precautions General Folic Acid in doses above 0. There is a potential danger in administering Folic Acid to patients with undiagnosed anemia, since Folic Acid may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

This may result in severe nervous system damage before the correct diagnosis is made. Adequate doses of vitamin B12 may prevent, halt, or improve the neurologic changes caused by pernicious anemia. Drug Interactions There is evidence that the anticonvulsant action of phenytoin is antagonized by Folic Acid.

A patient whose epilepsy is completely controlled by phenytoin may require increased doses to prevent convulsions if Folic Acid is given.

False low serum and red cell folate levels may occur if the patient has been taking antibiotics, such as tetracycline, which suppress the growth of Lactobacillus casei. Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals to evaluate carcinogenic potential and studies to evaluate the mutagenic potential or effect on fertility have not been conducted. Pregnancy Teratogenic Effects Pregnancy Category A Folic Acid is usually indicated in the treatment of megaloblastic anemias of pregnancy.

Studies in pregnant women have not shown that Folic Acid increases the risk of fetal abnormalities if administered during pregnancy. If the drug is used during pregnancy, the possibility of fetal harm appears remote. Because studies cannot rule out the possibility of harm, however, Folic Acid should be used during pregnancy only if clearly needed.

FOLIC ACID

Always take folic carton and this leaflet with you. Acta Derm Venereol ; Folate nutrition and growth in infancy. Plasma homocysteine response to folate intervention in young women. Homocysteine lowering interventions for preventing cardiovascular events. The challenge of stroke prevention. Benefits of docosahexaenoic acid, 500mg folic acid, folic acid, vitamin D and iodine on foetal folic infant brain development and function acid maternal supplementation during 500mg and lactation. The interventional folic of folic acid on the development of gastric and other gastrointestinal cancers - Clinical 500mg and follow- acid for seven years, 500mg folic acid. Scand 500mg Clin Lab Invest ; Breast ;20 Suppl 3: Folic Acid 5mg Tablets are acid in the treatment and prevention of certain types of anaemia low red blood cells500mg folic acid, e. Multiple-micronutrient supplementation for women during pregnancy. Concurrent use of folinic acid nebivolol 25mg methotrexate in rheumatoid arthritis, 500mg folic acid. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. Calcium supplementation during pregnancy may reduce preterm delivery in high-risk populations. Venous thrombosis associated with pernicious anaemia. Drug information contained herein may be time sensitive.

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