120mg codeine first time

It was a Thursday night, and I was looking to relax after a stressful week in school. I have a degree and honors thesis in neuroscience and advanced biopsychology training, so I usually consider myself very knowledgeable about drugs and dosages. I know that with me, codeine takes up to two hours before I feel that peak, so I have to be careful about re-dosing within that time period. Because of the acetaminophen content in Tylenol 3, I decided to supplement the pills with a codeine cough syrup I had left over from a respiratory illness.

The syrup had 10 mg in each spoonful, but also contained guafenisin. I know that I can handle 4 T3 pills so I took them and over the next two hours, took more and more of the syrup hoping to bring on the high, until I had taken 10 spoonfuls.

I also took 2 darvocets. This brought my total up to mg of codeine, too much acetaminophen, some guafenisin, and the propoxyphene of the darvocets. The most codeine I had taken before was mg, because I am a rather small girl and have a low tolerance to most drugs. I am very torn because I consider myself a responsible neuroscientist but then I can be rather impulsive and ignore my intuition and knowledge about drug actions.

Part of the problem was I really needed an escape so it was more about getting away from insurmountable stress than about leisure, which is always a dangerous state of mind in which to take drugs. About 2 hours into my experimenting, I came to an amazing state where my body felt like it was floating several feet above the bed. I had chill music on and spent most of the time staring at the tapestries I had hung around my giant bed in my dorm room, which I had to myself that semester. It was very much a mind trip, where I felt I couldn't keep all the thoughts in my head, they felt like they were trickling out and so was any sort of care or concern I had.

My body was so relaxed that even raising my head seemed like a huge effort and I felt like I couldn't move. About this time, my then boyfriend and still best friend of many years came in.

He is a complete non-drug user except for alcohol and, though he tries not to judge, he worries about me when I have my little 'experiences. I honestly wanted to be left alone because I didn't feel like I could interact with anyone at that point. He started to look worried and I realized I was getting increasingly unresponsive and disconnected from reality.

About two and a half hours after I started taking the drugs, my chest began to feel very tight, and I started crying out in pain. I felt like I was suffocating. Unresponsive Cough Dosage of codeine should not be increased if cough fails to respond; an unresponsive cough should be reevaluated in 5 days or sooner for possible underlying pathology, such as foreign body or lower respiratory tract disease.

Cardiovascular Effects Codeine may produce orthostatic hypotension in ambulatory patients. Bone-Marrow Depression Promethazine should be used with caution in patients with bone-marrow depression. Leukopenia and agranulocytosis have been reported, usually when promethazine hydrochloride has been used in association with other known marrow-toxic agents.

Constipation Codeine may cause or aggravate constipation. Other Considerations Administration of promethazine has been associated with reported cholestatic jaundice. Administration of codeine may be accomplished by histamine release and should be used with caution in atopic children.

Promethazine should be used cautiously in persons with impairment of liver function. Anticholinergic Effects Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.

Information for Patients Advise patients of the risks of respiratory depression and death with promethazine hydrochloride and codeine phosphate syrup in children younger than 18 years of age. Ambulatory patients should be told to avoid engaging in such activities until it is known that they do not become drowsy or dizzy from Promethazine and Codeine therapy.

Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Patients should be advised to measure Promethazine hydrochloride and codeine phosphate syrup with an accurate measuring device. A household teaspoon is not an accurate measuring device and could lead to overdosage, especially when a half a teaspoon is measured.

A pharmacist can recommend an appropriate measuring device and can provide instructions for measuring the correct dose. Patients should be advised to report any involuntary muscle movements. Avoid prolonged exposure to the sun. Codeine, like other narcotic analgesics, may produce orthostatic hypotension in some ambulatory patients. Patients should be cautioned accordingly. The use of benzodiazepines, opioids, antihistamines, antipsychotics, anti-anxiety agents, or other CNS depressants including alcohol concomitantly with promethazine hydrochloride and codeine phosphate syrup may cause an additive CNS depressant effect, profound sedation, respiratory depression, coma, and death and should be avoided see WARNINGS - Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants.

Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly.

The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride: Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. An increase in blood glucose has been reported in patients receiving promethazine.

Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of codeine or of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with these agents.

Codeine has been reported to show no evidence of carcinogenicity or mutagenicity in a variety of test systems, including the micronucleus and sperm abnormality assays and the Salmonella assay. Promethazine was nonmutagenic in the Salmonella test system of Ames. There are no studies in humans, and the significance of these findings to humans, if any, is not known. Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6. These doses are from approximately 2.

Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. There are no adequate and well-controlled studies of promethazine in pregnant women.

Animal reproduction studies have not been conducted with the drug combination — Promethazine and Codeine. It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

Promethazine hydrochloride and codeine phosphate syrup should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nonteratogenic Effects Dependence has been reported in newborns whose mothers took opiates regularly during pregnancy. Withdrawal signs include irritability, excessive crying, tremors, hyperreflexia, fever, vomiting, and diarrhea.

Signs usually appear during the first few days of life. Promethazine administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Labor and Delivery Narcotic analgesics cross the placental barrier. The closer to the delivery and the larger the dose used, the greater the possibility of respiratory depression in the newborn.

Narcotic analgesics should be avoided during labor if delivery of a premature infant is anticipated. If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression.

Limited data suggests that use of promethazine hydrochloride during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn.

See also Nonteratogenic Effects. Nursing Mothers Codeine and its active metabolite, morphine, are present in human milk. There are published studies and cases that have reported excessive sedation, respiratory depression, and death in infants exposed to codeine via breast milk. Women who are ultra-rapid metabolizers of codeine achieve higher than expected serum levels of morphine, potentially leading to higher levels of morphine in breast milk that can be dangerous in their breastfed infants.

In women with normal codeine metabolism normal CYP2D6 activity , the amount of codeine secreted into human milk is low and dose-dependent. There is no information on the effects of the codeine on milk production. Because of the potential for serious adverse reactions, including excess sedation, respiratory depression, and death in a breastfed infant, advise patients that breastfeeding is not recommended during treatment with promethazine hydrochloride and codeine phosphate syrup.

Withdrawal symptoms can occur in breastfed infants when maternal administration of an opioid analgesic is stopped, or when breast-feeding is stopped. It is not known whether promethazine is excreted in human milk. Risk factors include conditions associated with hypoventilation, such as postoperative status, obstructive sleep apnea, obesity, severe pulmonary disease, neuromuscular disease, and concomitant use of other medications that cause respiratory depression see WARNINGS - Ultra-Rapid Metabolism of Codeine and Respiratory Depression.

Geriatric Use Clinical studies of promethazine hydrochloride and codeine phosphate syrup did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine hydrochloride and codeine phosphate syrup and observed closely.

CNS depression, particularly respiratory depression, and to a lesser extent circulatory depression; light-headedness, dizziness, sedation, euphoria, dysphoria, headache, transient hallucination, disorientation, visual disturbances, and convulsions. When I was sitting at the computer, I was moving around a little, but in bed I lay motionless and the buzz returned strongly. From this point on the experience gets a little fuzzy, as I close my eyes and I think I may have been getting close to sleep.

With each different song coming through the headphones I would get a different mini-dream. As the song ended, I would snap out of the dream, and think about what had just happened, analyse the dream. Before long, the next song would start and I would get dragged into another daydream. This continued for quite a while, maybe songs, it was comparable to nitrous, the feeling of drifting away from reality into a dream world.

The daydreams are still continuing, though the body buzz has dimmed considerably. The experience feels a lot more psychological now, compared to the start where it was mainly physical sensations. I decide to turn the music off and try to get some sleep. I toss and turn for a few hours, not getting any real decent sleep until 5am nearly 7 hours after dropping. From here I sleep quite well until I had very strange dreams in this period, some which seemed extremely realistic.

I wake up feeling a little worse for wear, a few body aches and a mild headache. I notice these symptoms stick with me throughout the day, even now the next night after the experience I am getting warm flushes, have a headache and sore eyes. I am quite impressed with codeine, it is cheap and readily available and provides what I regard as a decent high.

It's not mindblowing, but nice for a quiet night in. I remember thinking that codeine would go quite nicely with nitrous or weed. Sadly I had both of these in my room, but didn't have any way to administer them. Sure I could have rolled a joint, but I just couldn't be bothered Next time definitely though!

I think codeine would be perfect for an ecstasy comedown, just to slow the mind down and relax. The after effects of codeine are a bit of an annoyance, but I think it is worth it. Overall something I would recommend to everyone to try - just remember that all opiates are addictive.

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